PARK8 / LRRK2 antibody

Principal name

PARK8 / LRRK2 antibody

Alternative names for PARK8 / LRRK2 antibody

Dardarin, Leucine-rich repeat serine/threonine-protein kinase 2

SwissProt ID

Q5S006 (Mouse), Q5S007 (Human)

Gene ID

120892 (LRRK2), 66725 (Lrrk2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Por (Porcine), Prim (Primate)

Available hosts

Rabbit, Mouse, Goat, Sheep

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoelectron Microscopy (EM), Frozen Sections (C)

Background of PARK8 / LRRK2 antibody

Leucine-rich repeat kinase 2 (LRRK2) is a 2,527 amino acid protein encoded by the PARK8 gene and belonging to the ROCO family of proteins. This protein family is characterized as having a unique interaction between the Roc domain and the intrinsic GTPase activity along with a COR domain. LRKK2 consists of 5 different domains; a tyrosine kinase-like MAPKKK-related domain, WD40 propeller motif repeats, a Roc (Ras-like small GTPase family) domain, a COR (C-terminal of Roc) domain, and an LRRK. LRRK2 is mainly localized to the cytoplasm and expression within tissue is most highly observed within the brain. It is found in lower levels within the liver, heart, lung, skeletal muscles, placenta, pancreas, and kidney. The exact function of LRRK2 is unknown; however mutations to any of the five domains are the most commonly known causes of Parkinson’s disease, both familial and sporadic. Further study of this protein may lead to a better understanding of the disease’s pathogenesis, as well as potential therapeutic markers.

General readings

1. Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R.
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease. Neuropathol Appl Neurobiol. 2007 Oct 26. PMID: 17971075
2. Sharma S, Bandopadhyay R, Lashley T, Renton AE, Kingsbury AE, Kumaran R, Kallis C, Vilariño-Güell C, O'Sullivan SS, Lees AJ, Revesz T, Wood NW, Holton JL.
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: A morphological and quantitative study. Neuropathol Appl Neurobiol. 2011 Jun 23.
PMID: 21696411
3. Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet. 2009 Nov 1;18(21):4022-34. PMID: 19640926

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PARK8 / LRRK2 antibody

Western Blot: LRRK2 antibody - Detection of LRRK2 in HeLa whole cell lysate (RIPA) using anti-LRRK2.  1:5,000 dilution, 1 minute ECL detection. Rabbit Purified Bov, Hu, Ms C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK8 / LRRK2 (Super Novus Pack) antibody

Staining of neurons and glia using NB110-55289 at 2.5ug/ml. Mouse brain, 40x. Rabbit Aff - Purified Bov, Hu, Ms ICC/IF, IP, P, WB
2 vials / €490.00
  Novus Biologicals Inc.

PARK8 / LRRK2 antibody

Immunohistochemistry: LRRK2 Antibody - IHC analysis of LRRK2 in mouse brain using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK8 / LRRK2 antibody

TA309737 in increasing amounts of human lymphoblast Rabbit Purified Hu, Ms, Por, Prim, Rt ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK8 / LRRK2 (C-term) antibody

(1.5ug/ml) staining of paraffin embedded Human Hippocampus CA4. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Hu E, EM, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK8 / LRRK2 antibody

Immunoblot versus rat brain low-speed pellet (LSP), mouse brain membranes (MBM) and wild-type (WT) and LRRK2 KO mouse samples probed with N138/6 (left) and K89/41 (right) TC supe. Mouse brain samples provided by Xiaojie Li, Ted Dawson and Valina Dawson (Johns Hopkins University) Mouse IgG1 N138/6 Supernatant Hu, Ms ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PARK8 / LRRK2 antibody

PARK8 / LRRK2 Mouse IgG2a N231B/34 Supernatant Hu, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PARK8 / LRRK2 antibody

Immunoblot versus rat brain low-speed pellet (LSP), mouse brain membranes (MBM) and wild-type (WT) and LRRK2 KO mouse samples probed with N138/6 (left) and K89/41 (right) TC supe. Mouse brain samples provided by Xiaojie Li, Ted Dawson and Valina Dawson (Johns Hopkins University) Mouse IgG1 N138/6 Purified Hu, Ms ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PARK8 / LRRK2 antibody

PARK8 / LRRK2 Mouse IgG2a N231B/34 Purified Hu, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PARK8 / LRRK2 (C-term) antibody

Figure 1. Western blot analysis of anti-LRRK2 Mab (Cat. #AM11056PU-N) to detect LRRK2 in mouse brain cell lysate. Mouse IgG1 133AT1218 Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PARK8 / LRRK2 (C-term) antibody

Figure 1. Western blot analysis of anti-LRRK2 Mab (Cat. #AM11057PU-N) to detect LRRK2 in mouse brain cell lysate. Mouse IgG1 133AT720 Purified Hu, Ms E, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PARK8 / LRRK2 (1-500) antibody

PARK8 / LRRK2 Mouse IgG1 S138-6 Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

PARK8 / LRRK2 (841-960) antibody

PARK8 / LRRK2 Mouse IgG2a S231B-34 Purified Hu, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

PARK8 / LRRK2 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with PARK8 (LRRK2) Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PARK8 / LRRK2 antibody

Tau-stable SY5Y cell image stained for endogenous LRRK (green) by AP13698PU-N (affinity purified), phosphorylated tau (red, monoclonal AT8) and nuclear staining by DAPI. Rabbit Ig Purified Hu, Ms ICC/IF, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PARK8 / LRRK2 antibody

PARK8 / LRRK2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

PARK8 / LRRK2 antibody

PARK8 / LRRK2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PARK8 / LRRK2 antibody

Detection limit for recombinant GST tagged LRRK2 is approximately 0.3ng/ml as a capture antibody. Mouse IgG1 3B2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PARK8 / LRRK2 antibody

PARK8 / LRRK2 Rabbit Hu C, E
0.4 ml / €390.00
  Abnova Taiwan Corp.

PARK8 / LRRK2 antibody

PARK8 / LRRK2 Rabbit Hu E, ICC/IF, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

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