PARL antibody

Principal name

PARL antibody

Alternative names for PARL antibody

PSARL, PRO2207, Presenilins-associated rhomboid-like protein mitochondrial, Mitochondrial intramembrane cleaving protease PARL

SwissProt ID

Q2KHV4 (Bovin), Q3B8P0 (Rat), Q58EK4 (Danre), Q5XJY4 (Mouse), Q9H300 (Human)

Gene ID

55486 (PARL), 381038 (Parl), 287979

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PARL antibody

PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL’s association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer’s disease through its associations with presenilin-1 and -2. Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Multiple isoforms of PARL are known to exist.

General readings

Walder,K., (2005) Diabetologia 48 (3), 459-468

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PARL antibody

  Rabbit Polyclonal PARL Antibody  
Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARL antibody

  Rabbit Polyclonal Anti-PARL Antibody  
WB Suggested Anti-PARL Antibody Titration: 0.5 ug/ml; Positive Control: Jurkat cell lysate;PARL is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PARL antibody

Western blot analysis using PARL antibody Cat.-No AM06254SU-N against truncated Trx-PARL recombinant protein (Lane 1) and truncated MBP-PARL(aa112-167) recombinant protein (Lane 2). Mouse IgG2b 8C4B2 Ascites Hu E, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

PARL (N-term) antibody

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PARL - human gene knockout kit via CRISPR

PARL - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PARL - human gene knockout kit via CRISPR

PARL - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PARL - human gene knockout kit via CRISPR

PARL - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PARL - human gene knockout kit via CRISPR

PARL - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Parl - mouse gene knockout kit via CRISPR

Parl - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Parl - mouse gene knockout kit via CRISPR

Parl - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Parl - mouse gene knockout kit via CRISPR

Parl - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Parl - mouse gene knockout kit via CRISPR

Parl - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PARL (mGFP-tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, PARL (mGFP-tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PARL (mGFP-tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PARL (mGFP-tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, PARL (Myc-DDK tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PARL (Myc-DDK tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, PARL (Myc-DDK tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PARL (Myc-DDK tagged) - Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Parl (GFP-tagged ORF) - Rat presenilin associated, rhomboid-like (Parl), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, Parl (GFP-tagged ORF) - Rat presenilin associated, rhomboid-like (Parl), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Parl (Myc-DDK-tagged ORF) - Rat presenilin associated, rhomboid-like (Parl), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, Parl (Myc-DDK-tagged ORF) - Rat presenilin associated, rhomboid-like (Parl), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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