PAX1 antibody

Principal name

PAX1 antibody

Alternative names for PAX1 antibody

Pax-1, HUP48, Paired box protein Pax-1

SwissProt ID

P09084 (Mouse), P15863 (Human), P47236 (Chick)

Gene ID

5075 (PAX1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of PAX1 antibody

Pax proteins are a family of transcription factors with a highly conserved paired domain; many members also contain a paired-type homeodomain and/or an octapeptide. strate that the transcriptional competence of a subfamily of Pax proteins is determined by a C-terminal regulatory module composed of activating and inhibitory sequences. Nine mammalian Pax genes are known and classified into four subgroups: Pax-1/9, Pax-2/5/8, Pax-3/7, and Pax-4/6. Most of these genes are involved in nervous system development. The homeobox, which encodes the DNA-binding homeo domain, is a DNA sequence motif present in several Drosophila developmental genes; it has been used to identify many homologous genes involved in mammalian development. The paired box is another conserved sequence motif, first identified in the paired (prd) and gooseberry (gsb) Drosophila homeo domain genes. The amino-terminal region of the paired domain, including one of the three predicted alpha-helices, is necessary and sufficient for binding. There are several members in the PAX family including PX1-PX11). Single amino acid substitution mutation in PAX1 causes formation of the mouse skeletal mutant undulated (un) (1).
Pax-1 is necessary for normal vertebral column formation along the entire axis, although the severity of the phenotype is strongest in the lumbar region and the tail. Pax-1-deficient mice lack vertebral bodies and intervertebral discs (2). The pattern-forming event of kidney tubulogenesis is initiated by the inductive transition of mesenchymal cells to epithelial phenotype; a transition that is critically dependent on the regulated expression of the developmental control gene, Pax-2. Pax2/5/8-related genes (egl-38 and pax-2) influence both somatic and germline cell death in C. elegans. Pax proteins act as transcriptional regulators of ced-9, the C. elegans bcl-2 gene. These results identify a mechanism for Pax2/5/8-mediated regulation of cell death, and underscore the importance of transcriptional regulation of core apoptotic pathway genes in influencing cell survival. Pax-6 is involved in the specification of subtypes of hindbrain motor neurons, presumably through the regulation of Islet-2 and Wnt-7b expression (3). Pax 8 gene has a size of approximately 26 kb and contains the coding sequence for mRNA in 12 exons (4).

General readings

Vatanavicharn,N., (2007) Am. J. Med. Genet. A 143 (19), 2292-2302

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAX1 (318-239) antibody

(0.2ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAX1 antibody

Predicted band size: 55 kDa . Positive control: K562 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/1200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAX1 antibody

WB Suggested Anti-PAX1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PAX1 antibody

Host:Rabbit; Target Name:PAX1; Sample Tissue:Human Fetal Muscle; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Can, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PAX1 control peptide

PAX1
0.1 mg / €250.00
  Acris Antibodies GmbH

PAX1 (C-term amidated) antibody

PAX1 Rabbit Aff - Purified Hu WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PAX1 antibody

Immunohistochemistry analyzes of Pax-1 antibody (Cat.-No.: AP20616PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PAX1 (C-term) antibody

Western blot analysis of PAX1 Antibody (C-term) Cat.-No AP53177PU-N in HepG2, MDA-MB453, 293, K562, MCF-7 cell line lysates (35ug/lane). This demonstrates the PAX1 antibody detected the PAX1 protein (arrow). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PAX1 (N-term) antibody

PAX1 Antibody (N-term) (Cat. #AP53178PU-N) western blot analysis in MDA-MB435 cell line lysates (35µg/lane).This demonstrates the PAX1 antibody detected the PAX1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PAX1 (Center) antibody

Human MCF-7; WB Suggested Anti-PAX1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: MCF7 cell lysate; PAX1 antibody - middle region (ARP34268_P050) in Human MCF-7 cells using Western Blot Rabbit Aff - Purified African clawed frog, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PAX1 antibody

Hum. Fetal Muscle; Host:Rabbit. Target Name:PAX1. Sample Tissue:Human Fetal Muscle. Antibody Dilution: 1.0ug/ml.; PAX1 antibody - middle region (ARP58040_P050) in Hum. Fetal Muscle cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PAX1 antibody

Western blot analysis of PAX1 expression in HEK293T (A); NIH3T3 (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PAX1 antibody

Western blot analysis of PAX1 expression in HEK293T (A); NIH3T3 (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PAX1 antibody

Western blot analysis of PAX1 expression in HEK293T (A); NIH3T3 (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PAX1 antibody

Immunohistochemistry: Pax-1 Antibody [NBP1-19767] -  Pax-1 Antibody [NBP1-19767] - paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

PAX1 overexpression lysate

PAX1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

PAX1 overexpression lysate

PAX1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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