PAX5 antibody

Principal name

PAX5 antibody

Alternative names for PAX5 antibody

Pax-5, BSAP, Paired box protein Pax-5, B-cell-specific transcription factor

SwissProt ID

Q02548 (Human), Q02650 (Mouse), Q9YH95 (Xenla)

Gene ID

5079 (PAX5)

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PAX5 antibody

Pax proteins are a family of transcription factors with a highly conserved paired domain; many members also contain a paired-type homeodomain and/or an octapeptide. strate that the transcriptional competence of a subfamily of Pax proteins is determined by a C-terminal regulatory module composed of activating and inhibitory sequences. Nine mammalian Pax genes are known and classified into four subgroups: Pax-1/9, Pax-2/5/8, Pax-3/7, and Pax-4/6. Most of these genes are involved in nervous system development. The homeobox, which encodes the DNA-binding homeo domain, is a DNA sequence motif present in several Drosophila developmental genes; it has been used to identify many homologous genes involved in mammalian development. The paired box is another conserved sequence motif, first identified in the paired (prd) and gooseberry (gsb) Drosophila homeo domain genes. The amino-terminal region of the paired domain, including one of the three predicted alpha-helices, is necessary and sufficient for binding. There are several members in the PAX family including PX1-PX11). Single amino acid substitution mutation in PAX1 causes formation of the mouse skeletal mutant undulated (un) (1).
Pax-1 is necessary for normal vertebral column formation along the entire axis, although the severity of the phenotype is strongest in the lumbar region and the tail. Pax-1-deficient mice lack vertebral bodies and intervertebral discs (2). The pattern-forming event of kidney tubulogenesis is initiated by the inductive transition of mesenchymal cells to epithelial phenotype; a transition that is critically dependent on the regulated expression of the developmental control gene, Pax-2. Pax2/5/8-related genes (egl-38 and pax-2) influence both somatic and germline cell death in C. elegans. Pax proteins act as transcriptional regulators of ced-9, the C. elegans bcl-2 gene. These results identify a mechanism for Pax2/5/8-mediated regulation of cell death, and underscore the importance of transcriptional regulation of core apoptotic pathway genes in influencing cell survival. Pax-6 is involved in the specification of subtypes of hindbrain motor neurons, presumably through the regulation of Islet-2 and Wnt-7b expression (3). Pax 8 gene has a size of approximately 26 kb and contains the coding sequence for mRNA in 12 exons (4). The gene Pax 5 belongs to the Pax gene family transcription factors that play an important role in organogenesis and in B cell ontogeny. It is expressed in B-cell non-Hodgkin’s lymphoma (B-NHL), Hodgkin’s lymphomas (HL) and neuroendocrine carcinomas. However, its expression in other tumor types is not fully explored. Despite its expression in a very small subset of carcinomas of epithelial origin, PAX5 is still a very reliable and good marker for diagnosing B-NHL, HL and neuroendocrine carcinomas.

General readings

Adams B, Dorfler P, Aguzzi A, Kozmik Z, Urbanek P, Maurer-Fogy I, Busslinger M.
Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.
Genes Dev 1992 Sep;6(9):1589-607.
PMID: 1516825

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAX5 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAX5 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PAX5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801884) Mouse IgG1 OTI3A7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAX5 antibody

Immunoperoxidase of monoclonal antibody to PAX5 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1.5 ug/ml] Mouse IgG1 8F9 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PAX5 (C-term) antibody

Human tonsil stained with anti-PAX5 antibody Cat.-No AM11183PU (Clone SP34). Rabbit SP34 Purified Hu F, P
0.5 ml / €540.00
  Acris Antibodies GmbH

PAX5 (C-term) antibody

Human tonsil stained with anti-PAX5 antibody Cat.-No AM11183PU (Clone SP34). Rabbit SP34 Purified Hu F, P
1 ml / €780.00
  Acris Antibodies GmbH

PAX5 (C-term) antibody

Human tonsil stained with anti-PAX5 antibody Cat.-No AM11183PU (Clone SP34). Rabbit SP34 Purified Hu F, P
0.1 ml / €300.00
  Acris Antibodies GmbH

PAX5 antibody

Human tonsil stained with Anti-Pax-5 antibody (Cat# AP15717PU). Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

PAX5 antibody

Human tonsil stained with Anti-Pax-5 antibody (Cat# AP15717PU). Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €440.00
  Acris Antibodies GmbH

PAX5 antibody

Human tonsil stained with Anti-Pax-5 antibody (Cat# AP15717PU). Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

PAX5 (N-term) antibody

TA302816 staining (3µg/ml) of U937 lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAX5 antibody

Western blot analysis of extracts from 293 cells, using Pax-5 Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAX5 antibody

Predicted band size: 42 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAX5 antibody

Western blot analysis of Daudi (lane 1) and A20 (lane 2) cells using anti-PAX-5 antibody (1H9). Rat IgG2a 1H9 Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAX5 antibody

Western blot analysis on 293 cell lysate using Pax-5 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAX5 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PAX5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801965) Mouse IgG2b OTIB6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAX5 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PAX5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801969) Mouse IgG2a OTIF9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAX5 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PAX5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802047) Mouse IgG2a OTIA6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAX5 antibody

Formalin fixed paraffin embedded human tonsil stained with PAX-5 antibody (Cat.AM00381SU-N). Rabbit IgG BV6 Supernatant Hu P
0.5 ml / €490.00
  Acris Antibodies GmbH

PAX5 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 8F9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PAX5 antibody

Western blot (WB) analysis of Pax-5 antibody (Cat.-No.: AP06279PU-N) in extracts from A549 cells. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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