PBK / TOPK antibody

Principal name

PBK / TOPK antibody

Alternative names for PBK / TOPK antibody

CT84, Nori-3, PDZ-binding kinase, SPK, Lymphokine-activated killer T-cell-originated protein kinase, Cancer/testis antigen 84, MAPKK-like protein kinase, T-LAK cell-originated protein kinase

SwissProt ID

Q6DHU8 (Danre), Q96KB5 (Human), Q9JJ78 (Mouse)

Gene ID

55872 (PBK)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP), Frozen Sections (C)

Background of PBK / TOPK antibody

A novel mitotic kinase, PDZ-binding kinase or PBK, which is upregulated in a variety of neoplasms including hematological malignancies, has been the focus of attention with a goal to understand its role in malignant conversion and to examine as a possible new therapeutic target in disparate types of cancer. Studies provide a plausible explanation for the role of PBK augmenting tumor cell growth following transient appearance in different types of progenitor cells in vivo (1). PBK is a newly identified member of a novel MEK3/6-related MAPKK that may be enrolled in the activation of lymphoid cells and support testicular functions (2). In vitro, PBK binds specifically to PDZ2 of hDlg through its C-terminal T/SXV motif. PBK and hDlg are phosphorylated at mitosis in HeLa cells, and the mitotic phosphorylation of PBK is required for its kinase activity. In vitro, cdc2/cyclin B phosphorylates PBK. This evidence shows how PBK could link hDlg or other PDZ-containing proteins to signal transduction pathways regulating the cell cycle or cellular proliferation (3).

General readings

Abe Y., et al. (2000) J Biol Chem. 275:21525-21531.Dougherty J D., et al. (2005) J Neurosci. 25:10773-10785.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PBK / TOPK antibody

Immunohistochemical analysis of paraffin-embedded colon cancer tissues (left) and ovarian cancer tissues (right) using PBK antibody Cat.-No AM06733SU-N with DAB staining. Mouse IgG2b 2C8 Ascites Hu E, F, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

PBK / TOPK antibody

PBK monoclonal antibody (M03), clone 2D6 Western Blot analysis of PBK expression in NIH/3T3 ( Cat # L018V1 ). Mouse IgG2a 2D6 Purified Hu, Ms, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK monoclonal antibody (M04), clone 3F7. Western Blot analysis of PBK expression in NIH/3T3 ( Cat # L018V1 ). Mouse IgG2a 3F7 Purified Hu, Ms, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

Immunoperoxidase of monoclonal antibody to PBK on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG2b 3A7 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

Immunoperoxidase of monoclonal antibody to PBK on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG2a 3A11 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK (C-term) antibody

Western blot analysis of PBK (arrow) using rabbit polyclonal PBK Antibody (C-term C300) (Cat.#TA302075).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PBK gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PBK / TOPK antibody

Immunohistochemistry (IHC) analysis of PBK/TOPK antibody (Cat.-No.: AP06557PU-N) in paraffin-embedded human breast tissue. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PBK / TOPK (N-term) antibody

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PBK / TOPK antibody

PBK / TOPK Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

Western Blot analysis of PBK expression in transfected 293T cell line (H00055872-T02) by PBK MaxPab polyclonal antibody.

Lane 1: PBK transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

Western Blot analysis of PBK expression in transfected 293T cell line (H00055872-T02) by PBK MaxPab polyclonal antibody.

Lane 1: PBK transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Mouse IgG2a 4E3 Purified Hu E
50 µg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Mouse IgG2a 4E3 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

Immunoperoxidase of monoclonal antibody to PBK on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG2b 4A10 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

Immunoperoxidase of monoclonal antibody to PBK on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG2b 1E11 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Mouse IgG2a 4D11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Mouse IgG2b 2A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Mouse IgG2b 2D2 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

PBK / TOPK antibody

PBK / TOPK Mouse IgG2a 5E1 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

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