PC1 / PC3 antibody

Principal name

PC1 / PC3 antibody

Alternative names for PC1 / PC3 antibody

PCSK1, Prohormone convertase 1, Prohormone convertase 3, Proprotein convertase 1, NEC1, NEC 1, Neuroendocrine convertase 1, BMIQ12

SwissProt ID

P28840 (Rat), P29120 (Human), P63239 (Mouse), Q9GLR1 (Bovin)

Gene ID

18548 (Pcsk1), 5122 (PCSK1), 2266 (FGG)

Available reactivities

Bov (Bovine), Ms (Mouse), Rt (Rat), Hu (Human), Mky (Monkey), Can (Canine), Por (Porcine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PC1 / PC3 antibody

PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alterte polyadenylation sites has been found for this gene. Multiple altertively spliced transcript variants have been described for this gene but their full length ture is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

General / background references:Wang J et al. The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site. Diabetes 50:534-9 (2001). PubMed PMID: 11246872
Furuta M et al. Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem 276:27197-202 (2001). PubMed PMID: 11356850
Muller L et al. Processing and sorting of the prohormone convertase 2 propeptide. J Biol Chem 275:39213-22 (2000). PubMed PMID: 10995742

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PC1 / PC3 (652-754) antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG3 3D2 Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PC1 / PC3 antibody

Immunoperoxidase of monoclonal antibody to PCSK1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG3 3D2 Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PC1 / PC3 antibody

WB Suggested Anti-PCSK1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Small Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PC1 / PC3 antibody

PC1 / PC3 Rabbit Serum Hu, Mky, Rt WB
0.1 ml / €530.00
  Acris Antibodies GmbH

PC1 / PC3 antibody

PC1 / PC3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PC1 / PC3 antibody

PC1 / PC3 Mouse IgG1 2G12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PC1 / PC3 antibody

Human Pancreas; Immunohistochemistry with Pancreas tissue at an antibody concentration of 5ug/ml using anti-PCSK1 antibody (ARP33848_P050); PCSK1 antibody - middle region (ARP33848_P050) in Human Pancreas cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PC1 / PC3 antibody

PC1 / PC3 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

PC1 / PC3 antibody

Western Blot: Prohormone Convertase 1 Antibody [NB120-3532] - Figure 1 illustrates Western blot detection of PC1 from mouse pituitary extract using NB120-3532. Rabbit IgG Aff - Purified Ms WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PC1 / PC3

PC1 / PC3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PC1 / PC3

PC1 / PC3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

11 Item(s)

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