PCK1 / PEPCK1 antibody

Principal name

PCK1 / PEPCK1 antibody

Alternative names for PCK1 / PEPCK1 antibody

PEPCK-C, PEPCKC, Phosphoenolpyruvate carboxylase, PEP carboxykinase, Phosphoenolpyruvate carboxykinase cytosolic [GTP]

SwissProt ID

P05153 (Chick), P07379 (Rat), P35558 (Human), Q8HYZ4 (Bovin), Q9Z2V4 (Mouse)

Gene ID

5105 (PCK1), 18534 (Pck1), 362282

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Pl (Plant), Bt (Bat), Eq (Equine), Hst (Hamster), Insect, Mky (Monkey), Op (Opossum), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Tr (Turkey), Bear, GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of PCK1 / PEPCK1 antibody

PCK1 is a main control point for the regulation of gluconeogenesis. PCK1, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of PCK1 can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human PCK1 with an internal ID of P03819

General readings

Willer CJ, Bonnycastle LL, Conneely KN, Duren WL, Jackson AU, Scott LJ, Narisu N, Chines PS, Skol A, Stringham HM, Petrie J, Erdos MR, Swift AJ, Enloe ST, Sprau AG, Smith E, Tong M, Doheny KF, Pugh EW, Watanabe RM, Buchanan TA, Valle TT, Bergman RN, Tuomilehto J, Mohlke KL, Collins FS, Boehnke M.
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.
Diabetes. 2007 Jan;56(1):256-64.
PMID: 17192490

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PCK1 / PEPCK1 antibody

  PCK1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PCK1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Rabbit Polyclonal Anti-PCK1 Antibody  
WB Suggested Anti-PCK1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Rabbit Polyclonal Anti-PCK1 Antibody  
WB Suggested Anti-PCK1 Antibody Titration: 1.0ug/ml; Positive Control: Fetal Brain Lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Rabbit Polyclonal PCK1 Antibody  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PCK1 Rabbit Polyclonal antibody. (TA590679) Rabbit IgG Purified Hu, Mky, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Goat Polyclonal Antibody against PCK1  
TA303224 (0.5µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Goat Anti-PCK1 / PEPCKC (internal) Antibody  
TA305772 (2ug/ml) staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Can, Hu, Ms, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Rabbit polyclonal anti-PEPCK-C antibody  
Western blot analysis of PEPCK-C with lysate from rat kidney (Lane 1), 3T3 cells (Lane 2) and Jurkat cells (Lane 3). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Rabbit Polyclonal Anti-PCK1 Antibody  
WB Suggested Anti-PCK1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 antibody

  Rabbit Polyclonal Anti-PCK1 Antibody  
PCK1 / PEPCK1 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PCK1 / PEPCK1 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PCK1 / PEPCK1 (513-524) antibody

Human Liver (formalin-fixed, paraffin-embedded) stained with PCK1 antibody AP22519PU-N at 2 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Hst, Hu, Insect, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Tr, Xen E, P
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PCK1 - human gene knockout kit via CRISPR

PCK1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PCK1 - human gene knockout kit via CRISPR

PCK1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PCK1 - human gene knockout kit via CRISPR

PCK1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PCK1 - human gene knockout kit via CRISPR

PCK1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pck1 - mouse gene knockout kit via CRISPR

Pck1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pck1 - mouse gene knockout kit via CRISPR

Pck1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pck1 - mouse gene knockout kit via CRISPR

Pck1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pck1 - mouse gene knockout kit via CRISPR

Pck1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PCK1 / PEPCK1

  Recombinant protein of human phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1)  
PCK1 / PEPCK1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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