PDCD10 antibody

Principal name

PDCD10 antibody

Alternative names for PDCD10 antibody

CCM3, TFAR15, Programmed cell death protein 10, Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15

SwissProt ID

Q5ZIV5 (Chick), Q6NX65 (Rat), Q8AVR4 (Xenla), Q8VE70 (Mouse), Q9BUL8 (Human)

Gene ID

11235 (PDCD10)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PDCD10 antibody

Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011). 
The CCM-3 is fused to a N-terminal His-tag (6x His).

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDCD10 antibody

Predicted band size: 25 kDa . Positive control: Hela, Jurkat and 231 cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lane1: Hela cell lysate Lane2: Jurkat cell lysate Lane3: 231 cell lysate Lysates: 50 ug per lane Primary antibody: 1/200dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDCD10 antibody

Predicted band size: 25 kDa . Positive control: Hela cell, human fetal brain tissue and K562 cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lane1: Hela cell lysate Lane2: Human fetal brain tissue lysate Lane3: K562 cell lysate Lysates: 50 ug per lane Primary antibody: 1/200dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDCD10 antibody

Immunofluorescence staining (green) of Human foreskin (cryo-section of unfixed tissue) with anti-Human CCM3 antibody Cat.-No. AP26023PU (K5548, dilution1/50). A) Note specific staining in the epidermis and in the wall of microvessels. B) Negative control of a consecutive section. Nuclei counter-stained with Dapi (blue). <em>Specimen provided by Prof. Dr. J. Wilting, Goettingen.The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany.</em> Rabbit Aff - Purified Hu ICC/IF, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

PDCD10 antibody

Immunofluorescence staining (green) of Human foreskin (cryo-section of unfixed tissue) with anti-Human CCM3 antibody Cat.-No. AP26023PU (K5548, dilution1/50). A) Note specific staining in the epidermis and in the wall of microvessels. B) Negative control of a consecutive section. Nuclei counter-stained with Dapi (blue). <em>Specimen provided by Prof. Dr. J. Wilting, Goettingen.The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany.</em> Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

PDCD10 antibody

PDCD10 Mouse IgG1 1B11 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDCD10 antibody

PDCD10 Rabbit Purified Hu P, WB
0.1 mg / €380.00
  Novus Biologicals Inc.

PDCD10 antibody

PDCD10 Rabbit Purified Hu P, WB
0.2 mg / €530.00
  Novus Biologicals Inc.

PDCD10 antibody

Immunohistochemistry-Paraffin: PDCD10 Antibody [NBP1-86574] Immunohistochemical staining of human adrenal gland shows strong positivity in cortical cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDCD10 (transcript variant 1)

PDCD10 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PDCD10 (His-tag)

SDS-PAGE analysis of recombinant human CCM3. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditionsand and stained with Silver stain. Human Purified > 95 % by SDS-PAGE and silver stain E. coli
20 µg / €200.00
  Acris Antibodies GmbH

PDCD10

PDCD10 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PDCD10

PDCD10 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PDCD10

PDCD10 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PDCD10

PDCD10 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PDCD10 overexpression lysate

PDCD10 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

PDCD10 overexpression lysate

PDCD10 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

PDCD10 overexpression lysate

PDCD10 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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