PDCL antibody

Principal name

PDCL antibody

Alternative names for PDCL antibody

Phosducin-like protein, PHLP

SwissProt ID

Q13371 (Human), Q2HJA9 (Bovin), Q63737 (Rat), Q9DBX2 (Mouse)

Gene ID

5082 (PDCL)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of PDCL antibody

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

General readings

Thibault C., et al. (1999) Biochim. Biophys. Acta. 1444:346-354Olsen J.V., et al. (2006) Cell. 127:635-648

  1. Quick-Filters:
  2. Highly Validated (2)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDCL antibody

Sample(30 ug whole cell lysate). A:H1299. 10% SDS PAGE. TA308930 diluted at 1:3000 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDCL antibody

Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu E, ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDCL antibody

Western blot analysis of PDCL in K562 cell lysate with PDCL antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PDCL antibody

PDCL Mouse IgG2a 4G5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDCL antibody

ELISA: PDCL Antibody [37010002] Rabbit Hu E, WB
50 µg / €400.00
  Novus Biologicals Inc.

PDCL antibody

Immunofluorescence: PDCL Antibody [NBP1-32523] - analysis of paraformaldehyde-fixed HeLa, using PHLP antibody at 1:200 dilution. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

PDCL antibody

Immunohistochemistry-Paraffin: PDCL Antibody [NBP1-85078] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

PDCL antibody

Immunohistochemistry-Paraffin: PDCL Antibody [NBP1-85079] - Immunohistochemical staining of human skeletal muscle shows distinct cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDCL

PDCL Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PDCL (1-301, His-tag)

PDCL Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €730.00
  Acris Antibodies GmbH

PDCL (1-301, His-tag)

PDCL Human Purified > 90 % by SDS - PAGE E. coli
20 µg / €300.00
  Acris Antibodies GmbH

PDCL

PDCL Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PDCL overexpression lysate

PDCL overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

13 Item(s)

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