PDE12 antibody

Principal name

PDE12 antibody

Alternative names for PDE12 antibody

2'-PDE, 2-PDE, 2',5'-phosphodiesterase 12

SwissProt ID

Q08DF7 (Bovin), Q3TIU4 (Mouse), Q6AXQ5 (Rat), Q6L8Q7 (Human)

Gene ID

201626 (PDE12)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P)

Background of PDE12 antibody

2\'-PDE is an enzyme that cleaves 2\',5\'-phosphodiester bond linking adenosines of the 5\'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2\'-PDE also cleaves 3\',5\'-phosphodiester bond of oligoadenylates. 2\'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

General readings

Kohno, T., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 5), 520-522 (2010)
Kubota, K., et al. J. Biol. Chem. 279(36):37832-37841(2004)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE12 antibody

PDE12 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
  OriGene Technologies, Inc.

PDE12 (C-term) antibody

PDE12 Rabbit Ig Aff - Purified Hu F, WB
  Acris Antibodies GmbH

PDE12 antibody

PDE12 Mouse Hu WB
  Abnova Taiwan Corp.

PDE12 antibody

PDE12 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
  AVIVA Systems Biology

PDE12 antibody

PDE12 Rabbit Aff - Purified Hu, Ms WB
  Novus Biologicals Inc.

PDE12 antibody

PDE12 Rabbit IgG Aff - Purified Hu P, WB
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  


PDE12 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
  OriGene Technologies, Inc.

7 Item(s)

per page
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