PDE3A antibody

Principal name

PDE3A antibody

Alternative names for PDE3A antibody

Phosphodiesterase 3A, Phosphodiesterase-3A cGMP-inhibited, CGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, Cyclic GMP-inhibited phosphodiesterase A

SwissProt ID

Q14432 (Human), Q62865 (Rat), Q9Z0X4 (Mouse)

Gene ID

5139 (PDE3A), 50678 (Pde3a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PDE3A antibody

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-PDE11) based on their kinetic properties and inhibition to various pharmacological agents. The members of the PDE families are known as cGMP inhibited PDEs. The PDE3 enzymes bind both cGMP and cAMP with different affinities (cAMP 4-10-fold than cGMP). The phosphodiesterase type-3 (PDE3) family is comprised of 2 genes (PDE3 A and B). PDE3A is a 125 kDa protein and is expressed in various tissues (myocardium, vascular and non vascular smooth muscles, megakaryocytes and a subset of neurons (Snyder 1999; Maecci et al., 1992). PDE3A has two splice variants and are expressed in adipocyte tissue, hepatocyte, kidney, spermatocytes and embryonic neuroepithelium (Reinhatdt et. al., 1995). Both PDE3A and PDE3B are therapeutic targets for the treatment of obesity as inhibition of PDE3 increase the lipolytic activity and alter the insulin secretion and its response. PDE3 inhibitors also promote thermogenic and cardiotonic effects in animals.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE3A (N-term) antibody

Anti-PDE3A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE3A (N-term) antibody

Anti-PDE3A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE3A antibody

Anti-PDE3A antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE3A antibody

WB Suggested Anti-PDE3A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDE3A antibody

Western blot using AP00653SU-N (1:20,000) against lysate from COS cells transfected with the indicated human PDE isoform Rabbit Serum Hu, Ms, Rt C, IP, WB
0.1 ml / €420.00
  Acris Antibodies GmbH

PDE3A Control Peptide

PDE3A
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE3A antibody

PDE3A Rabbit Aff - Purified Hu, Ms, Rt E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE3A antibody

PDE3A Goat Aff - Purified Hu, Ms, Rt E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE3A antibody

PDE3A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PDE3A antibody

Detection limit for recombinant GST tagged PDE3A is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 5C12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDE3A antibody

PDE3A Mouse IgG2b 2D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDE3A antibody

PDE3A Rabbit Hu IP
0.1 mg / €560.00
  Abnova Taiwan Corp.

PDE3A antibody

PDE3A Rabbit Hu, Ms, Rt C, IP, WB
50 µl / €560.00
  Abnova Taiwan Corp.

PDE3A antibody

Human MCF-7; WB Suggested Anti-PDE3A Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: MCF7 cell lysate; PDE3A antibody - N-terminal region (ARP44356_P050) in Human MCF-7 cells using Western Blot Rabbit Aff - Purified Chk, Hu, Por WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE3A

PDE3A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PDE3A

PDE3A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PDE3A overexpression lysate

PDE3A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PDE3A (mGFP-tagged) - Human phosphodiesterase 3A, cGMP-inhibited (PDE3A), 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE3A (mGFP-tagged) - Human phosphodiesterase 3A, cGMP-inhibited (PDE3A), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE3A (Myc-DDK tagged) - Human phosphodiesterase 3A, cGMP-inhibited (PDE3A) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE3A (Myc-DDK tagged) - Human phosphodiesterase 3A, cGMP-inhibited (PDE3A) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Pde3a (GFP-tagged ORF) - Rat phosphodiesterase 3A, cGMP inhibited (Pde3a), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pde3a (GFP-tagged ORF) - Rat phosphodiesterase 3A, cGMP inhibited (Pde3a), 200 uL, >10^7 TU/mL  
200 µl / €2,340.00
  OriGene Technologies, Inc.

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