PDE3B antibody

Principal name

PDE3B antibody

Alternative names for PDE3B antibody

Phosphodiesterase 3B, Phosphodiesterase-3B cGMP-inhibited, HcGIP1, CGIPDE1, CGI-PDE B, CGIP, CGIP1, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, Cyclic GMP-inhibited phosphodiesterase B

SwissProt ID

Q13370 (Human), Q61409 (Mouse), Q63085 (Rat)

Gene ID

5140 (PDE3B), 18576 (Pde3b), 29516

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Can (Canine), Eq (Equine), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of PDE3B antibody

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-PDE11) based on their kinetic properties and inhibition to various pharmacological agents. The members of the PDE3 families are known as cGMP inhibited PDEs. The PDE3 enzymes bind both cGMP and cAMP with different affinities (cAMP 4-10-fold than cGMP). The phosphodiesterase type-3 (PDE3) family is comprised of 2 genes (PDE3A and PDE3B). PDE3A is a 145 kDa protein and is expressed in various tissues (myocardium, vascular and non vascular smooth muscles, megakaryocytes and a subset of neurons (Snyder 1999; Maecci et al., 1992). PDE3B is 1112 amino acids long and has two splice variants which are expressed in adipocyte tissue, hepatocyte, kidney, spermatocytes and embryonic neuroepithelium (Reinhatdt et. al., 1995). Both PDE3A and PDE3B are therapeutic targets for the treatment of obesity as inhibition of PDE3 increase the lipolytic activity and alter the insulin secretion and its response. PDE3 inhibitors also promote thermogenic and cardiotonic effects in animals.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yamano, Y., et al. Int. J. Cancer 126(2):437-449(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Hanson, M.S., et al. Am. J. Physiol. Heart Circ. Physiol. 295 (2), H786-H793 (2008)
Raymond, D.R., et al. Cell. Signal. 19(12):2507-2518(2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE3B (Phospho) antibody

PDE3B Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

PDE3B antibody

  Rabbit polyclonal anti-PDE3B antibody  
Western blot analysis of PDE3B with lysate from 3T3 cells. Rabbit Purified Hu, Ms, Rt WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

PDE3B antibody

  Rat Anti-Mouse PDE3B Purified (25 ug)  
Lysates prepared from mouse heart (lane 1) or lymph node cells (lane 2) were run under reducing conditions on a 3-8% Tris-Acetate gel. The membrane was probed with 2 ug/mL of Anti-Mouse PDE3B Purified, followed by Anti-Rat IgG HRP. Rat SMCP3B Purified Ms WB
25 µg / €150.00
  OriGene Technologies, Inc.

PDE3B antibody

  Rabbit Polyclonal Anti-PDE3B Antibody  
WB Suggested Anti-PDE3B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDE3B antibody

Western blot using AP00654SU-N (1:20,000) against lysate from COS cells transfected with the indicated human PDE isoform. Rabbit Serum Hu, Ms, Rt C, IP, WB
0.1 ml / €420.00
  Acris Antibodies GmbH

PDE3B Control Peptide

PDE3B
0.25 mg / €250.00
  Acris Antibodies GmbH

PDE3B antibody

PDE3B Rabbit Aff - Purified Hu, Ms, Rt E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE3B antibody

PDE3B Goat Aff - Purified Hu, Ms, Rt E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE3B Control Peptide

PDE3B
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE3B (Center) antibody

Confocal immunofluorescent analysis of PDE3B Antibody (Center) Cat.-No AP53235PU-N with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Rabbit Ig Aff - Purified Hu F, ICC/IF, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PDE3B - human gene knockout kit via CRISPR

PDE3B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PDE3B - human gene knockout kit via CRISPR

PDE3B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE3B - human gene knockout kit via CRISPR

PDE3B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE3B - human gene knockout kit via CRISPR

PDE3B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE3B

  Recombinant protein of human phosphodiesterase 3B, cGMP-inhibited (PDE3B)  
PDE3B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PDE3B (mGFP-tagged) - Human phosphodiesterase 3B, cGMP-inhibited (PDE3B), 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE3B (mGFP-tagged) - Human phosphodiesterase 3B, cGMP-inhibited (PDE3B), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE3B (Myc-DDK tagged) - Human phosphodiesterase 3B, cGMP-inhibited (PDE3B) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE3B (Myc-DDK tagged) - Human phosphodiesterase 3B, cGMP-inhibited (PDE3B) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Pde3b (GFP-tagged ORF) - Rat phosphodiesterase 3B, cGMP-inhibited (Pde3b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pde3b (GFP-tagged ORF) - Rat phosphodiesterase 3B, cGMP-inhibited (Pde3b), 200 uL, >10^7 TU/mL  
200 µl / €2,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, Pde3b (Myc-DDK-tagged ORF) - Rat phosphodiesterase 3B, cGMP-inhibited (Pde3b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pde3b (Myc-DDK-tagged ORF) - Rat phosphodiesterase 3B, cGMP-inhibited (Pde3b), 200 uL, >10^7 TU/mL  
200 µl / €2,064.00
  OriGene Technologies, Inc.

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