PDE4A antibody

Principal name

PDE4A antibody

Alternative names for PDE4A antibody

Phosphodiesterase 4A, Phosphodiesterase-4A cAMP-specific, PDE46, PDE4, DPDE2, PDE4A4, PDE4A4B, PDE4A11, PDE4A7, PDE4A6, PDE4A1, RD1, PDE4A8A, 2EL, PDE4A10, PDE4A8, cAMP-specific 3',5'-cyclic phosphodiesterase 4A

SwissProt ID

O89084 (Mouse), O89085 (Cavpo), P27815 (Human), P54748 (Rat), Q8WUQ3 (Human), Q9W4T4 (Drome)

Gene ID

5141 (PDE4A), 18577 (Pde4a), 25638

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P)

Background of PDE4A antibody

Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. In brain more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes (1). Members of the PDE4A, B and D family are associated with GPCRs (adrenergic and dopaminergic) signaling (6, 7). In testis PDE4A variants are expressed exclusively in primary and secondary germ cells and are believed to be responsible for normal spermatogenesis (8). PDE4 enzymes are also important molecular targets for variety of therapeutic agents like antidepressants, anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprised of 4 genes (PDE4A, B, C and D); each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants (2). Rolipram, an antidepressant drug, inhibits all the members of PDE4 family in mM concentration range. In rodents, inhibition of PDE4 enzymes attenuated short- and long-term memory impairment produced by scopolamine and MK801 administration (3). Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A and phosphatases (4). Two conserved phosphorylation motifs have been identified in PDE4A subtype variants (i) Phosphorylation at PKA site and (ii) an ERK kinase site. Phosphorylation at PKA site resulted in significant increase I enzymatic activity of PDE4A variants. Phosphorylation state, protein-protein interactions and cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization and cAMP-dependent signaling (5).

  1. Quick-Filters:
  2. Highly Validated (11)

Items 1 to 20 of 45 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI1E3 (formerly 1E3)  
Immunofluorescent staining of HT29 cells using anti-PDE4A mouse monoclonal antibody (TA501152). Mouse IgG2a OTI1E3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI1F5 (formerly 1F5)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501153, Dilution 1:50) Mouse IgG2b OTI1F5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI1C8 (formerly 1C8)  
Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501192, Dilution 1:50) Mouse IgG1 OTI1C8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI3D4 (formerly 3D4)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501198, Dilution 1:50) Mouse IgG1 OTI3D4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI7D11 (formerly 7D11)  
Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501199, Dilution 1:50) Mouse IgG1 OTI7D11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI2G2 (formerly 2G2)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501200, Dilution 1:50) Mouse IgG1 OTI2G2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI7B11 (formerly 7B11)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501201, Dilution 1:50) Mouse IgG2b OTI7B11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI6B6 (formerly 6B6)  
Immunohistochemical staining of paraffin-embedded colon tissue within the normal limits using anti-PDE4A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501202, Dilution 1:50) Mouse IgG1 OTI6B6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI6D6 (formerly 6D6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501203, Dilution 1:50) Mouse IgG1 OTI6D6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI5C6 (formerly 5C6)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501206, Dilution 1:50) Mouse IgG2b OTI5C6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

  anti-PDE4A mouse monoclonal antibody, clone OTI8B7 (formerly 8B7)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-PDE4A  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501207, Dilution 1:50) Mouse IgG1 OTI8B7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PDE4A antibody

Western blot using AP00655SU-N (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform. Rabbit Serum Hu, Ms, Rt C, IP, WB
0.1 ml / €420.00
  Acris Antibodies GmbH

PDE4A control peptide

PDE4A
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE4A (C-term) antibody

PDE4A Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt E, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE4A control peptide

PDE4A
0.25 mg / €250.00
  Acris Antibodies GmbH

PDE4A (phosphospecific) antibody

PDE4A Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt E, F, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE4A control peptide

PDE4A
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE4A1 control peptide

PDE4A1
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE4A1 (isoform specific) antibody

PDE4A1 Rabbit HRP Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PDE4A1 (isoform specific) antibody

PDE4A1 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Items 1 to 20 of 45 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn