PDE4C antibody

Principal name

PDE4C antibody

Alternative names for PDE4C antibody

Phosphodiesterase 4C, Phosphodiesterase-4C cAMP-specific, DPDE1, PDE21, PDE4C1, PDE4C2, PDE4C3, PDE4C4, PDE4C5, PDE4C6, PDE4C7, cAMP-specific 3',5'-cyclic phosphodiesterase 4C

SwissProt ID

P14644 (Rat), Q08493 (Human), Q3UEI1 (Mouse), Q9W4S9 (Drome)

Gene ID

5143 (PDE4C), 110385 (Pde4c)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PDE4C antibody

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. cAMP-specific phosphodiesterase type-4 (PDE4) family is comprised of 4 genes (PDE4 A, B, C and D) with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). The cAMP-dependent protein kinase A modulates the enzyme activity of some PDE4 family members by phosphorylation/dephosphorylation mechanisms (2, 3). Such short-term regulatory mechanisms are necessary for rapid changes in the cAMP levels in cells. PDE4-family selective inhibitor, rolipram inhibits all members of the PDE4 family in mM range. At present PDE4 subtype selective and variant selective inhibitors are not available. In rodents inhibition of PDE4 enzymes by rolipram attenuated short- and long-term memory impairment produced by the administration of scopolamine and MK801 (3, 4). Interaction of these enzymes with cellular scaffolding proteins plays important role in PDE4 compartmentalization and cAMP-dependent signaling. Members of the PDE4A and D subtype variants specifically interact with cytoskeletal proteins with SH3 domains or RACK and AKAP for cellular compartmentalization. In brain PDE4A, B and D are associated with GPCRs signaling (5, 6). Little expression of PDE4C was observed in brain, the PDE4C is expressed in other peripheral tissues including testis, white blood cells and heart.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE4C antibody

  Rabbit Polyclonal antibody to PDE4C (phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila))  
Sample(30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308689 diluted at 1:1000 Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDE4C antibody

  Rabbit polyclonal anti-PDE4C antibody  
Western blot analysis of extracts from A549 cells, RAW264.7 cells and HuvEc cells, using PDE4C antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

PDE4C - human gene knockout kit via CRISPR

PDE4C - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE4C - human gene knockout kit via CRISPR

PDE4C - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde4c - mouse gene knockout kit via CRISPR

Pde4c - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pde4c - mouse gene knockout kit via CRISPR

Pde4c - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde4c - mouse gene knockout kit via CRISPR

Pde4c - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde4c - mouse gene knockout kit via CRISPR

Pde4c - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE4C (transcript variant 2)

  Recombinant protein of human phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) (PDE4C), transcript variant 2  
PDE4C Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PDE4C (mGFP-tagged)-Human phosphodiesterase 4C, cAMP-specific (PDE4C), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE4C (mGFP-tagged)-Human phosphodiesterase 4C, cAMP-specific (PDE4C), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,540.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE4C (Myc-DDK-tagged)-Human phosphodiesterase 4C, cAMP-specific (PDE4C), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE4C (Myc-DDK-tagged)-Human phosphodiesterase 4C, cAMP-specific (PDE4C), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,380.00
  OriGene Technologies, Inc.

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