PDE4C antibody

Principal name

PDE4C antibody

Alternative names for PDE4C antibody

Phosphodiesterase 4C, Phosphodiesterase-4C cAMP-specific, DPDE1, PDE21, PDE4C1, PDE4C2, PDE4C3, PDE4C4, PDE4C5, PDE4C6, PDE4C7, cAMP-specific 3',5'-cyclic phosphodiesterase 4C

SwissProt ID

P14644 (Rat), Q08493 (Human), Q3UEI1 (Mouse), Q9W4S9 (Drome)

Gene ID

5143 (PDE4C)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of PDE4C antibody

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. cAMP-specific phosphodiesterase type-4 (PDE4) family is comprised of 4 genes (PDE4 A, B, C and D) with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). The cAMP-dependent protein kinase A modulates the enzyme activity of some PDE4 family members by phosphorylation/dephosphorylation mechanisms (2, 3). Such short-term regulatory mechanisms are necessary for rapid changes in the cAMP levels in cells. PDE4-family selective inhibitor, rolipram inhibits all members of the PDE4 family in mM range. At present PDE4 subtype selective and variant selective inhibitors are not available. In rodents inhibition of PDE4 enzymes by rolipram attenuated short- and long-term memory impairment produced by the administration of scopolamine and MK801 (3, 4). Interaction of these enzymes with cellular scaffolding proteins plays important role in PDE4 compartmentalization and cAMP-dependent signaling. Members of the PDE4A and D subtype variants specifically interact with cytoskeletal proteins with SH3 domains or RACK and AKAP for cellular compartmentalization. In brain PDE4A, B and D are associated with GPCRs signaling (5, 6). Little expression of PDE4C was observed in brain, the PDE4C is expressed in other peripheral tissues including testis, white blood cells and heart.

General readings

General / background references:Zhang HT et al. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology 23:198-204 (2000). PubMed PMID: 10882846
Beavo JA Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 75:725-48 (1995). PubMed PMID: 7480160
Farooqui SM et al. Antibodies against synthetic peptides predicted from the nucleotide sequence of D2 receptor recognize native dopamine receptor protein in rat striatum. J Neurochem 57:1363-9 (1991). PubMed PMID: 1832709

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE4C antibody

Sample(30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308689 diluted at 1:1000 Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDE4C antibody

Western blot analysis of extracts from A549 cells, RAW264.7 cells and HuvEc cells, using PDE4C antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDE4C control peptide

PDE4C
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE4C (C-term) (C1-C3) antibody

PDE4C Rabbit Aff - Purified Hu, Mky, Ms, Rt IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE4C antibody

PDE4C Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PDE4C antibody

PDE4C Mouse IgG3 4E5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDE4C antibody

PDE4C monoclonal antibody (M03), clone 6A10 Western Blot analysis of PDE4C expression in A-431 ( Cat # L015V1 ). Mouse IgG1 6A10 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

PDE4C antibody

Western blot analysis of PDE4C expression in HEK293T (A); SHSY5Y (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PDE4C antibody

Western blot analysis of PDE4C expression in HEK293T (A); SHSY5Y (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PDE4C antibody

Western blot analysis of PDE4C expression in HEK293T (A); SHSY5Y (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PDE4C antibody

PDE4C Rabbit Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PDE4C antibody

Western Blot:  PDE4C Antibody [NBP1-32341]-(30 µg of whole cell lysate) A:293T 7.5% SDS PAGE diluted at 1:1000 Rabbit IgG Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE4C (transcript variant 2)

PDE4C Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PDE4C

PDE4C Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PDE4C

PDE4C Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

15 Item(s)

per page
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