PDE6D / PDED antibody

Principal name

PDE6D / PDED antibody

Alternative names for PDE6D / PDED antibody

Phosphodiesterase 6D, Phosphodiesterase-6D cGMP-specific, GMP-PDE delta, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, Protein p17

SwissProt ID

O43924 (Human), O55057 (Mouse), Q95142 (Bovin), Q9VLJ0 (Drome), Q9XT54 (Canfa)

Gene ID

5147 (PDE6D), 281976

Available reactivities

Bov (Bovine), Hu (Human), Can (Canine), Mky (Monkey), Ms (Mouse), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PDE6D / PDED antibody

The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways, such as insulin secretion, platelet aggregation, smooth muscle relaxation, olfaction, and vision. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. While mammalian PDEs are divided into major families based on their substrate specificities, kinetic properties, allosteric regulators, inhibitor sensitivities, and amino acid sequences, each family and even members within a family display distinct tissue, cell, and subcellular expression patters. This suggests that individual PDE family members are involved in discrete signal transduction pathways.
PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.

General readings

Zhang H., et al, (2007) Proc Natl Acad Sci U S A. 104(21):8857-62.
Dekomien., G. et al. (2003) Genet Sel Evol. 35(4):445-56.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE6D / PDED antibody

Sample (30 ug of whole cell lysate). A: MOLT4 . 12% SDS PAGE. TA308586 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDE6D / PDED antibody

PDE6D / PDED Mouse IgG2b 4H6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDE6D / PDED antibody

Immunofluorescence of monoclonal antibody to PDE6D on HeLa cell. [antibody concentration 20 ug/ml] Mouse IgG2b 5C7 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PDE6D / PDED antibody

Western Blot: PDE5D Antibody [NBP1-32730] - (30 ug of whole cell lysate) A: MOLT4 12% SDS PAGE diluted at 1:1000 Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

PDE6D / PDED antibody

Immunohistochemistry-Paraffin: PDE6D Antibody [NBP1-86275] Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in Goblet cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE6D / PDED

PDE6D / PDED Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PDE6D / PDED (full length, N-term HIS tag)

PDE6D / PDED Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

PDE6D / PDED (1-150, His-tag)

PDE6D / PDED Human Purified > 90 % by SDS-PAGE E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

PDE6D / PDED (1-150, His-tag)

PDE6D / PDED Human Purified > 90 % by SDS-PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

PDE6D / PDED

PDE6D / PDED Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PDE6D / PDED

PDE6D / PDED Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

PDE6D / PDED

SDS-Page: PDE5D Protein [NBP1-44480] - PDE6D, 18.4 kDa (158aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE Human Purified
0.1 mg / €440.00
  Novus Biologicals Inc.

12 Item(s)

per page
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