PDE7A antibody
Principal name
PDE7A antibody
Alternative names for PDE7A antibody
Phosphodiesterase 7A, PDE7, HCP1, TM22, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ncbi ID
9606, NP_001229247.1, NP_002594, NM_002603, NM_001122759, NM_002604
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P)
Background of PDE7A antibody
The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G-protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messengers which play important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cAMP in T-Lymphocytes are phosphodiesterase type 7. The cAMP-specific phosphodiesterase type-7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). PDE7A has two splice variants (PDE7A1 and PDE7A2), the two are divergent at the 5’ end in human and PDE7A1 is more hydrophobic (2). Like other PDEs, human PDE7A gene has 456 amino acids and migrates at an apparent molecular weight of 53-55 kDa on reduced SDS-PAGE. The PDE7A has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE7A protein showed significant homology to other cAMP-dependent PDEs (23%) with in the catalytic domain. PDE7A is widely expressed in various tissues including skeletal muscle, T lymphocytes, brain, pancreas,



Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA317151 | PDE7A (N-term) antibody |
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Phosphodiesterase 7a / PDE7A Rabbit Polyclonal (N-Terminus) Antibody | |||||||
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Rabbit | Aff - Purified | Hu | P |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
TA338280 | PDE7A antibody |
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Rabbit Polyclonal Anti-PDE7A Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
€360.00
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OriGene Technologies, Inc. | |||||||
AP00659SU-N | PDE7A antibody |
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Rabbit | Serum | Hu, Ms, Rt | C, IP, WB |
0.1 ml /
€420.00
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Acris Antibodies GmbH |
Lysates
Catalog No. | ||
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LY419221 | PDE7A overexpression lysate |
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0.1 mg /
€495.00
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OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC214749L2V | Lenti ORF particles, PDE7A (mGFP-tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 1, 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC220940L2V | Lenti ORF particles, PDE7A (mGFP-tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€1,051.00
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OriGene Technologies, Inc. | ||
RC214749L1V | Lenti ORF particles, PDE7A (Myc-DDK tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 1 , 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||
RC220940L1V | Lenti ORF particles, PDE7A (Myc-DDK tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 2 , 200 uL, >10^7 TU/mL |
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200 µl /
€938.00
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OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
Catalog No. | ||
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MR207723L2V | Lenti ORF particles, Pde7a (GFP-tagged) - Mouse phosphodiesterase 7A (Pde7a), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€1,133.00
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OriGene Technologies, Inc. | ||
MR207723L1V | Lenti ORF particles, Pde7a (Myc-DDK-tagged) - Mouse phosphodiesterase 7A (Pde7a), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€1,010.00
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OriGene Technologies, Inc. | ||