PDE7A antibody

Principal name

PDE7A antibody

Alternative names for PDE7A antibody

Phosphodiesterase 7A, PDE7, HCP1, TM22, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

SwissProt ID

O08593 (Rat), P70453 (Mouse), Q13946 (Human)

Gene ID

5150 (PDE7A), 18583 (Pde7a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PDE7A antibody

The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G-protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messengers which play important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cAMP in T-Lymphocytes are phosphodiesterase type 7. The cAMP-specific phosphodiesterase type-7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). PDE7A has two splice variants (PDE7A1 and PDE7A2), the two are divergent at the 5’ end in human and PDE7A1 is more hydrophobic (2). Like other PDEs, human PDE7A gene has 456 amino acids and migrates at an apparent molecular weight of 53-55 kDa on reduced SDS-PAGE. The PDE7A has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE7A protein showed significant homology to other cAMP-dependent PDEs (23%) with in the catalytic domain. PDE7A is widely expressed in various tissues including skeletal muscle, T lymphocytes, brain, pancreas,

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE7A (N-term) antibody

Anti-PDE7A antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE7A antibody

WB Suggested Anti-PDE7A Antibody; Titration: 1.0 ug/ml; Positive Control: 721_B Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDE7A antibody

Western blot using AP00659SU-N (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform. Rabbit Serum Hu, Ms, Rt C, IP, WB
0.1 ml / €420.00
  Acris Antibodies GmbH

PDE7A Control Peptide

PDE7A
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE7A antibody

Figure 1. Western Blot using PDE7A antibody (AP10247PU-N):
Lane 1: Lungs 
Lane 2: Kidney
Lane 3: Testis 
Lane 4: Pancreas
Lane 5: Heart
Lane 6: Brain
Lane 7: Heart Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE7A antibody

PDE7A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE7A

PDE7A Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

PDE7A

PDE7A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PDE7A

PDE7A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PDE7A overexpression lysate

PDE7A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PDE7A (mGFP-tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE7A (mGFP-tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE7A (mGFP-tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE7A (mGFP-tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE7A (Myc-DDK tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE7A (Myc-DDK tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE7A (Myc-DDK tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE7A (Myc-DDK tagged) - Human phosphodiesterase 7A (PDE7A), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €910.00
  OriGene Technologies, Inc.

14 Item(s)

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