PDE7B antibody

Principal name

PDE7B antibody

Alternative names for PDE7B antibody

Phosphodiesterase 7B, MGC88256, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, rolipram-insensitive phosphodiesterase type 7

SwissProt ID

Q8VIE4 (Rat), Q9NP56 (Human), Q9QXQ1 (Mouse)

Gene ID

27115 (PDE7B), 140929, 6027115 (IPR000194)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bt (Bat), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Hst (Hamster), Por (Porcine), Rb (Rabbit), Gorilla, GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PDE7B antibody

The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G-protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messengers which play important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cAMP in T-Lymphocytes are phosphodiesterase type 7. The cAMP-specific phosphodiesterase type-7 (PDE7) family is comprised of 2 genes (PDE7A and PDE7B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). PDE7B has three splice variants (PDE7B1 = 446 amino acid; PDE7B2 =359 amino acids and PDE7B3 = 459 amino acids. Both PDE7B2 ad PDE7B3 posses unique N-terminal sequences.
Like other PDEs, human PDE7B gene products have an apparent molecular weight of 53-55 kDa on reduced SDS-PAGE (2). As in PDE7A, the PDE7B has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE7B protein showed significant homology to other cAMP-dependent PDEs (23%) with in the catalytic domain. PDE7B is expressed in various tissues including skeletal muscle, heart, lung and testis (2).

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21(7):1223-1232(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE7B (N-term) antibody

Anti-PDE7B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE7B antibody

Anti-PDE7B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE7B (C-term) antibody

Anti-PDE7B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE7B antibody

WB Suggested Anti-PDE7B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDE7B Control Peptide

PDE7B
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE7B antibody

Western blot with AP10248PU-N 
(1:1000). Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE7B Control Peptide

PDE7B
0.25 mg / €250.00
  Acris Antibodies GmbH

PDE7B antibody

PDE7B Rabbit Aff - Purified Hu IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE7B (C-term) antibody

Western blot analysis of PDE7B Antibody (C-term) Cat.-No AP53239PU-N in ZR-75-1 cell line lysates (35ug/lane). This demonstrates the PDE7B antibody detected the PDE7B protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PDE7B antibody

PDE7B Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PDE7B antibody

Western Blot analysis of PDE7B expression in transfected 293T cell line (H00027115-T01) by PDE7B MaxPab polyclonal antibody.

Lane1:PDE7B transfected lysate(49.5 KDa).
Lane2:Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PDE7B antibody

PDE7B Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PDE7B antibody

PDE7B Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PDE7B antibody

Western blot of Pde7b polyclonal antibody ( Cat # PAB8978 ) with protein-coupled Pde7b. Antibody dilution at 1 : 750. Rabbit Ms, Rt IP, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

PDE7B antibody

Human MCF-7; WB Suggested Anti-PDE7B Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: MCF7 cell lysate; PDE7B antibody - middle region (ARP55364_P050) in Human MCF-7 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PDE7B antibody

Western Blot: PDE7B Antibody [NBP1-52979] - This Anti-PDE7B antibody was used in Western Blot of MCF7     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

PDE7B antibody

Immunohistochemistry-Paraffin: PDE7B Antibody [NBP1-85987] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in subsets of tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE7B

PDE7B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PDE7B

PDE7B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PDE7B

PDE7B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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