PDE8A antibody

Principal name

PDE8A antibody

Alternative names for PDE8A antibody

Phosphodiesterase 8A, FLJ16150, HsT19550, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, cAMP-specific cyclic nucleotide phosphodiesterase 8A

SwissProt ID

O60658 (Human), O88502 (Mouse), Q9UMB7 (Human)

Gene ID

5151 (PDE8A), 18584 (Pde8a)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of PDE8A antibody

Cyclic nucleotides are important intracellular second messengers which play important role variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cAMP in to AMP are phosphodiesterase type 8. The cAMP-specific phosphodiesterase type-8 (PDE8) family is comprised of 2 genes (PDE8A and PDE8B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). PDE8 family is a high affinity cAMP-specific, IBMX sensitive PDE. Like other PDEs, human PDE8A has 713 amino acids and migrate at apparent 100 kDa on reduced and non-reduced SDS-PAGE. The PDE8 has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy-terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE8A protein showed significant homology to other cAMP-dependent PDEs (23%) with in the catalytic domain. PDE8A is widely expressed in various tissues in contrast to PDE8B that is exclusively expressed in thyroid gland. The PDE8A transcripts are found in brain, pancreas, placenta, thyroid, spleen, trachea, prostate, and uterus.

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE8A (N-term) antibody

  PDE8A Rabbit Polyclonal (N-Terminus) Antibody  
PDE8A Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

PDE8A antibody

  Rabbit Polyclonal Anti-PDE8A Antibody - C-terminal region  
WB Suggested Anti-PDE8A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDE8A antibody

  Rabbit Polyclonal Anti-PDE8A Antibody - C-terminal region  
WB Suggested Anti-PDE8A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDE8A (Center) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PDE8A antibody (Center) (AP11453PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PDE8A - human gene knockout kit via CRISPR

PDE8A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PDE8A - human gene knockout kit via CRISPR

PDE8A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE8A - human gene knockout kit via CRISPR

PDE8A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE8A - human gene knockout kit via CRISPR

PDE8A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde8a - mouse gene knockout kit via CRISPR

Pde8a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pde8a - mouse gene knockout kit via CRISPR

Pde8a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde8a - mouse gene knockout kit via CRISPR

Pde8a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde8a - mouse gene knockout kit via CRISPR

Pde8a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PDE8A (mGFP-tagged) - Human phosphodiesterase 8A (PDE8A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE8A (mGFP-tagged) - Human phosphodiesterase 8A (PDE8A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE8A (mGFP-tagged)-Human phosphodiesterase 8A (PDE8A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE8A (mGFP-tagged)-Human phosphodiesterase 8A (PDE8A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE8A (Myc-DDK tagged) - Human phosphodiesterase 8A (PDE8A), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE8A (Myc-DDK tagged) - Human phosphodiesterase 8A (PDE8A), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, PDE8A (Myc-DDK-tagged)-Human phosphodiesterase 8A (PDE8A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDE8A (Myc-DDK-tagged)-Human phosphodiesterase 8A (PDE8A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,530.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Pde8a (GFP-tagged) - Mouse phosphodiesterase 8A (Pde8a), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pde8a (GFP-tagged) - Mouse phosphodiesterase 8A (Pde8a), 200 uL, >10^7 TU/mL  
200 µl / €1,550.00
  OriGene Technologies, Inc.

Lenti ORF particles, Pde8a (Myc-DDK-tagged) - Mouse phosphodiesterase 8A (Pde8a), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pde8a (Myc-DDK-tagged) - Mouse phosphodiesterase 8A (Pde8a), 200 uL, >10^7 TU/mL  
200 µl / €1,390.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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