PDE8B antibody

Principal name

PDE8B antibody

Alternative names for PDE8B antibody

Phosphodiesterase 8B, hsPDE8B, PIG22, PPNAD3, ADSD, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, Cell proliferation-inducing gene 22 protein

SwissProt ID

O95263 (Human)

Gene ID

8622 (PDE8B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Eq (Equine), Gorilla

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PDE8B antibody

Cyclic nucleotides are important intracellular second messengers which play important role variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cAMP in to AMP are phosphodiesterase type 8. The cAMP-specific phosphodiesterase type-8 (PDE8) family is comprised of 2 genes (PDE8A and PDE8B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1). PDE8 family is a high affinity cAMP-specific, IBMX sensitive PDE. Like other PDEs, human PDE8A has 713 amino acids and migrate at apparent 100 kDa on reduced and non-reduced SDS-PAGE. The PDE8 has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE8A protein showed significant homology to other cAMP-dependent PDEs (23%) with in the catalytic domain. PDE8A is widely expressed in various tissues in contrast to PDE8B that is exclusively expressed in thyroid gland. The PDE8A transcripts are found in brain, pancreas, placenta, thyroid, spleen, trachea, prostate, and uterus.

9 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE8B antibody

Anti-PDE8B antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE8B antibody

Anti-PDE8B antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

PDE8B Control Peptide

PDE8B
0.1 mg / €270.00
  Acris Antibodies GmbH

PDE8B antibody

PDE8B Rabbit Aff - Purified Hu, Mky, Ms, Rt IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PDE8B antibody

PDE8B Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

PDE8B antibody

Western Blot: PDE8B Antibody [NB300-644] - Western Blot of PDE8B using rat testis and heart membranes. Antibody (NB300-644) dilution 1:500. Molecular weight marker positions are marked on the left. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PDE8B antibody

Western Blot: PDE8B Antibody [NBP1-71816] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells.  Antibodies: Affinity purified rabbit anti-PDE8B antibody NBP1-71816 used for WB at 1 ug/ml (A and B) and used for IP at 6 ug/mg lysate.  PDE8B was also immunoprecipitated by rabbit anti-PDE8B antibody NBP1-71817, which recognizes a downstream epitope. Rabbit Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PDE8B antibody

PDE8B Rabbit Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PDE8B antibody

Immunohistochemistry-Paraffin: PDE8B Antibody [NBP1-86280] Immunohistochemical staining of human thyroid gland shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

9 Item(s)

per page
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