PDE9A antibody

Principal name

PDE9A antibody

Alternative names for PDE9A antibody

Phosphodiesterase 9A, Phosphodiesterase PDE9A21, HSPDE9A2, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

SwissProt ID

O70628 (Mouse), O76083 (Human), Q86WN8 (Human)

Gene ID

5152 (PDE9A), 18585 (Pde9a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PDE9A antibody

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes which catalyzes the hydrolysis of cyclic adenosine 30,50-monophosphate (cAMP) and/or cyclic guanosine 30,50-monophosphate (cGMP); and PDE9A (high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A) is a PDE member which hydrolyzes the second messenger cGMP, an important regulator of several critical cellular physiological processes. PDE9A activity gets modulated by metal ions and it can bind 2 divalent metal cations per subunit - site 1 binds zinc ions, whereas, site 2 preferentially associates with magnesium and/or manganese ions. PDE9A is expressed in most of the solid tissues and because of its location as well as contribution to the regulation of steady-state cellular concentrations of cyclic nucleotides, PDE9A has been suggested as a potential candidate for diseases such as bipolar affective disorder and its overexpression has been linked to Down syndrome. Moreover, PDE9A deficient mice fed a high-fat diet have been reported to exhibit a reduced weight gain and fat mass compared with wild-type mice.

General readings

Huai,Q., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9624-9629

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE9A antibody

  Rabbit Polyclonal antibody to PDE9A (phosphodiesterase 9A)  
Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308688 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDE9A antibody

  Rabbit Polyclonal PDE9A Antibody  
Western Blot: PDE9A Antibody [TA336701] - WB analysis of PDE9A in HeLa whole cell lysate. Rabbit Purified Hu, Ms, Rt C, ICC/IF, IP, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

PDE9A antibody

  Rabbit Polyclonal Anti-PDE9A Antibody (Internal)  
PDE9A Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

PDE9A antibody

Human Adrenal Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4E1 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PDE9A antibody

Western blot using AP00660SU-N (1:2,000) against lysate from Insect cells transfected with the indicated human PDE isoform. Rabbit Serum Hu, Ms, Rt C, IP, WB
0.1 ml / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PDE9A - human gene knockout kit via CRISPR

PDE9A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PDE9A - human gene knockout kit via CRISPR

PDE9A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE9A - human gene knockout kit via CRISPR

PDE9A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDE9A - human gene knockout kit via CRISPR

PDE9A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde9a - mouse gene knockout kit via CRISPR

Pde9a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pde9a - mouse gene knockout kit via CRISPR

Pde9a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde9a - mouse gene knockout kit via CRISPR

Pde9a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pde9a - mouse gene knockout kit via CRISPR

Pde9a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDE9A (transcript variant 13)

  Purified recombinant protein of Homo sapiens phosphodiesterase 9A (PDE9A), transcript variant 13  
PDE9A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PDE9A (transcript variant 3)

  Purified recombinant protein of Homo sapiens phosphodiesterase 9A (PDE9A), transcript variant 3  
PDE9A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PDE9A (transcript variant 9)

  Purified recombinant protein of Homo sapiens phosphodiesterase 9A (PDE9A), transcript variant 9  
PDE9A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PDE9A overexpression lysate

PDE9A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

PDE9A overexpression lysate

PDE9A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

PDE9A overexpression lysate

PDE9A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

PDE9A overexpression lysate

PDE9A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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