PDHX / PDX1 antibody

Principal name

PDHX / PDX1 antibody

Alternative names for PDHX / PDX1 antibody

E3-binding protein, E3BP, proX, Pyruvate dehydrogenase protein X component mitochondrial, Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, Lipoyl-containing pyruvate dehydrogenase complex component X

SwissProt ID

O00330 (Human), O94709 (Schpo), P16451 (Yeast), P22439 (Bovin), Q8BKZ9 (Mouse)

Gene ID

8050 (PDHX), 27402 (Pdhx)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ChIP assay (ChIP), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunohistochemistry (IHC)

Background of PDHX / PDX1 antibody

PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.

General readings

Li Y, et al. {beta}-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1. Diabetes 54(2): 482-91 (2005) PMID: 15677506

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDHX / PDX1 antibody

Western blot analysis of anti-PDX1 Antibody (T11) (Cat.#TA302073) in NCI-H460 cell line lysates (35ug/lane).PDX1-T11(arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PDHX / PDX1 antibody

Immunofluorescence of purified MaxPab antibody to PDHX on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

PDHX / PDX1 (C-term) antibody

Western blot analysis of lysate from WiDr cell line, using hPDX1R444(Cat. #TA302074). TA302074 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. Rabbit Ig Purified Hu, Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PDHX / PDX1 antibody

PDHX polyclonal antibody (A01), Lot # 051213JCO1 Western Blot analysis of PDHX expression in HepG2 ( Cat # L019V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PDHX / PDX1 antibody

PDHX / PDX1 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

PDHX / PDX1 antibody

PDHX / PDX1 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PDHX / PDX1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with PDHX polyclonal antibody ( Cat # PAB3860 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PDHX / PDX1 antibody

Western blot analysis of PDHX polyclonal antibody ( Cat # PAB3861 ) in NCI-H460 cell line lysates ( 35 µg/lane ) .PDHX ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PDHX / PDX1 antibody

PDHX polyclonal antibody ( Cat # PAB6779 ) staining of paraffin embedded human pancreas. A ) Microwaved antigen retrieval with citrate buffer pH 6 ( 3 µg/ml ) , HRP-staining. B ) Microwaved antigen retrieval with Tris/EDTA buffer pH9 ( 1 µg/ml ) , HRP-staining. Goat Hu E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PDHX / PDX1 antibody

PDHX / PDX1 Rabbit Aff - Purified Ms IHC
25 µg / €630.00
  Funakoshi Co., Ltd.

PDHX / PDX1 antibody

Immunohistochemistry: PDHX Antibody [NB100-1496] - NB100-1496 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3ug/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1ug/ml) , HRP-staining. Goat Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PDHX / PDX1 antibody

Mouse pancreatic beta T cell lysate was probed with anti-PDX1 (1:20,000 dilution). Arrow indicates PDX1. Rabbit Serum Ms, Rt ChIP, IP, P, WB
50 µl / €360.00
  Novus Biologicals Inc.

PDHX / PDX1 antibody

Immunohistochemistry-Paraffin: PDHX Antibody [NBP1-84079] - Immunohistochemical staining of human stomach shows strong cytoplasmic(granular pattern) and nuclear positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

PDHX / PDX1 antibody

Immunohistochemistry-Paraffin: PDHX Antibody [NBP1-84080] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDHX / PDX1 (transcript variant 1)

PDHX / PDX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PDHX / PDX1 (54-501, His-tag)

PDHX / PDX1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €730.00
  Acris Antibodies GmbH

PDHX / PDX1 (54-501, His-tag)

PDHX / PDX1 Human Purified > 85 % by SDS - PAGE E. coli
20 µg / €300.00
  Acris Antibodies GmbH

Antibody Pairs

Catalog No.    

PDHX (Human) IP-WB Antibody Pair

PDHX (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PDHX 293T Cell Transient Overexpression Lysate(Denatured)

PDHX 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

PDHX overexpression lysate

PDHX overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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