PDIA2 antibody

Principal name

PDIA2 antibody

Alternative names for PDIA2 antibody

PDIA-2, PDIP, Protein disulfide-isomerase A2, Protein Disulfide Isomerase, ER marker, Pancreas-specific protein disulfide isomerase

SwissProt ID

D3Z6P0, Q13087 (Human), Q5RCH2 (Ponab)

Gene ID

64714 (PDIA2), 287164 (Pdia2), 69191

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Sh (Sheep), Can (Canine), Chk (Chicken), Por (Porcine), Xen (Xenopus), Prim (Primate), Eq (Equine)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PDIA2 antibody

The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

General readings

Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA.
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration.
Nature. 2006 May 25;441(7092):513-7.
PMID: 16724068

13 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDIA2 antibody

TA303215 (0.03µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PDIA2 antibody

Western Blot: PDI Antibody - Western Blot on normal human brain. Rabbit Purified Bov, Hu, Ms, Prim, Rt C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDIA2 antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and liver cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using PDIA2 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDIA2 antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and lung cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using PDIA2 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDIA2 antibody

WB Suggested Anti-PDIA2 Antibody; Titration: 1.0 ug/ml; Positive Control: Hela Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDIA2 (477-481) antibody

TA348975 (0.1 ug/ml) staining of Human (A), Mouse (B) and Rat (C) Pancreas lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PDIA2 antibody

PDIA2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

PDIA2 antibody

PDIA2 polyclonal antibody ( Cat # PAB7246 ) ( 0.03 µg/ml ) staining of human pancreas lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PDIA2 antibody

PDIA2 Rabbit Bov, GP, Hst, Hu, Mky, Ms, Rt, Sh C, ICC/IF, IP, WB
0.1 ml / €560.00
  Abnova Taiwan Corp.

PDIA2 antibody

PDIA2 Rabbit IgG Bov, Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

PDIA2 antibody

Western Blot: PDIA2 Antibody [NB100-58967] - NB100-58967 (0.03ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDIA2

PDIA2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PDIA2 overexpression lysate

PDIA2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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