PDZD1 antibody

Principal name

PDZD1 antibody

Alternative names for PDZD1 antibody

PDZK1, NHERF3, NHERF-3, NHE-RF3, NaPi-Cap1, CAP70, PDZ domain-containing protein 1, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Sodium-hydrogen exchanger regulatory factor 3

SwissProt ID

Q3T0X8 (Bovin), Q5T2W1 (Human), Q865P3 (Rabit), Q9JIL4 (Mouse), Q9JJ40 (Rat)

Gene ID

5174 (PDZK1), 59020 (Pdzk1), 65144

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PDZD1 antibody

Scaffold or adaptor proteins recruits and/or anchor their binding partners to specific subcellular locations, serving as a platform to regulate interactions between proteins involved in diverse sigl transduction pathways, and PDZK1 (PDZ domain-containing protein 1) is a scaffold protein belonging to NHERFs family. PDZK1 expression is largely limited to epithelial cells and is mainly expressed in rel proximal epithelial cells, hepatocytes, and at a lower level in other epithelial as well as certain endothelial cells. PDZK1 has four PDZ domains which facilitates its interaction with its binding partners, including ion transporters (e.g. CFTR, OCTN1/OCTN2 etc) and several GPCRs (e.g. HTR2B, SSTR family members). Through its interaction with HDL and SR-BI, PDZK1 can play role in reverse cholesterol transport and for HDL-mediated vascular re-endothelialisation. When complex with SLC9A3R1, PDZK1 cluster proteins that are functiolly dependent in a mutual fashion and modulate the trafficking as well as the activity of associated membrane proteins. PDZK1 plays a role in cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 also implicates in connecting SCARB1 with cellular machineries for intracellular cholesterol transport and/or metabolism and regulation of proximal tubular +-dependent inorganic phosphate cotransport.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
LaLonde, D.P., et al. Mol. Biol. Cell 21(9):1519-1529(2010)
Polasek, O., et al. Croat. Med. J. 51(1):32-39(2010)
Gunjaca, G., et al. Croat. Med. J. 51(1):23-31(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDZD1 antibody

  Rabbit anti-PDZK1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PDZK1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PDZD1 antibody

  Rabbit Polyclonal PDZK1 Antibody  
Western Blot: PDZK1 Antibody [TA336647] - WB analysis of PDZK1 in fetal  human liver lysate. Rabbit Purified Bov, Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PDZD1 antibody

  Rabbit Polyclonal Anti-PDZK1 Antibody  
WB Suggested Anti-PDZK1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDZD1 antibody

  Rabbit Polyclonal Anti-PDZK1 Antibody  
WB Suggested Anti-PDZK1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysatePDZK1 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDZD1 (1-520) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1C3-2B11 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PDZD1 antibody

The cell lysates of HeLa (40ug) and 293T (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PDZK1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT1A2 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

PDZD1 antibody

The cell lysates of HeLa (40ug) and 293T (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PDZK1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT1A2 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

PDZD1 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with PDZK1 Antibody (Center) Cat.-No AP53250PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PDZK1 - human gene knockout kit via CRISPR

PDZK1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PDZK1 - human gene knockout kit via CRISPR

PDZK1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDZK1 - human gene knockout kit via CRISPR

PDZK1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PDZK1 - human gene knockout kit via CRISPR

PDZK1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pdzk1 - mouse gene knockout kit via CRISPR

Pdzk1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pdzk1 - mouse gene knockout kit via CRISPR

Pdzk1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pdzk1 - mouse gene knockout kit via CRISPR

Pdzk1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDZD1

  Recombinant protein of human PDZ domain containing 1 (PDZK1)  
PDZD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PDZD1 (1-519, His-tag)

PDZD1 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

PDZD1 (1-519, His-tag)

PDZD1 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

PDZK1 overexpression lysate

PDZK1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PDZK1 (mGFP-tagged) - Human PDZ domain containing 1 (PDZK1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, PDZK1 (mGFP-tagged) - Human PDZ domain containing 1 (PDZK1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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