PDZRN3 antibody

Principal name

PDZRN3 antibody

Alternative names for PDZRN3 antibody

SEMCAP3, SEMACAP3, LNX3, KIAA1095, E3 ubiquitin-protein ligase PDZRN3, Ligand of Numb protein X 3

SwissProt ID

P68907 (Rat), Q69ZS0 (Mouse), Q9UPQ7 (Human)

Gene ID

23024 (PDZRN3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PDZRN3 antibody

PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDZRN3 antibody

Host: Rabbit; Target Name: PDZRN3; Sample Tissue: Fetal Thymus lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

PDZRN3 antibody

Western Blot analysis of PDZRN3 expression in transfected 293T cell line (H00023024-T01) by PDZRN3 MaxPab polyclonal antibody.

Lane 1: PDZRN3 transfected lysate(117.26 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PDZRN3 antibody

PDZRN3 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PDZRN3 antibody

PDZRN3 Rabbit IgG Aff - Purified Hu, Ms WB
50 µg / €680.00
  Funakoshi Co., Ltd.

PDZRN3 antibody

Immunohistochemistry-Paraffin: PDZRN3 Antibody [NBP1-81441] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PDZRN3

PDZRN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PDZRN3

PDZRN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PDZRN3 293T Cell Transient Overexpression Lysate(Denatured)

PDZRN3 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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