PEAR1 antibody

Principal name

PEAR1 antibody

Alternative names for PEAR1 antibody

MEGF12, Platelet endothelial aggregation receptor 1, Multiple epidermal growth factor-like domains protein 12, Multiple EGF-like domains protein 12

SwissProt ID

Q5VY43 (Human), Q8VIK5 (Mouse)

Gene ID

375033 (PEAR1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PEAR1 antibody

PEAR1 Antibody: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that sigls upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.

General readings

Johnson, A.D., et al. Nat. Genet. 42(7):608-613(2010)
Jones, C.I., et al. Blood 114(7):1405-1416(2009)
Herrera-Galeano, J.E., et al. Arterioscler. Thromb. Vasc. Biol. 28(8):1484-1490(2008)
Nanda, N., et al. J. Biol. Chem. 280(26):24680-24689(2005)
Nanda, N., et al. J. Biol. Chem. 280(26):24680-24689(2005)

4 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PEAR1 (C-term) antibody

Western blot analysis of PEAR1 in rat kidney tissue lysate with PEAR1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEAR1 control peptide

Western blot analysis of PEAR1 in rat kidney tissue lysate with PEAR1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
50 µg / €160.00
  Acris Antibodies GmbH

PEAR1 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with PEAR1 Antibody (C-term) Cat.-No AP53251PU-N, which was peroxidase conjugated to the secondary antibody and followed by  DAB staining. This data demonstrates the use of the PEAR1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PEAR1 antibody

Immunohistochemistry-Paraffin: PEAR1 Antibody [NBP1-90449] Immunohistochemical staining of human bone marrow shows strong positivity in megakaryocytes and platelets. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

4 Item(s)

per page
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