PEBP1 / RKIP antibody

Principal name

PEBP1 / RKIP antibody

Alternative names for PEBP1 / RKIP antibody

PEBP-1, PEBP, Prostatic-binding protein, PBP, Raf kinase inhibitor protein, HCNPpp, Phosphatidylethanolamine-binding protein 1

SwissProt ID

P13696 (Bovin), P30086 (Human), P31044 (Rat), P70296 (Mouse), Q3YIX4 (Canfa), Q8MK67 (Rabit)

Gene ID

29542 (Pebp1), 5037 (PEBP1), 23980

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Fi (Fish), Hst (Hamster), Insect, Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Tr (Turkey), Bear, Dros (Drosophila), African clawed frog

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PEBP1 / RKIP antibody

Raf kise inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding protein (PEBP) family that associates with Raf-1 and the MEK and MAP kises. RKIP has been shown to complex with Raf-1, MEK, and ERK. Although MEK and ERK can simultaneously bind RKIP, the association between Raf-1 and RKIP and that of RKIP and MEK are mutually exclusive. Thus, RKIP competitively disrupts the Raf-1-MEK complex and effectively termites sigl transmission from Raf-1 to MAP kises. The inhibitory effect of RKIP on MAP kise sigling is elimited by PKC phosphorylation of RKIP at Ser153. PKC phosphorylation on Ser153 also promotes the association of RKIP with GRK2, which prevents GRK2-dependent interlization of GPCR. RKIP also interacts with modules of the NF-?B pathway, including NF-?B-inducing kise (NIK), TAK1, IKKa and IKKß. These interactions antagonize cytokine-induced activation of the NF-?B pathway. Restoration of RKIP expression is associated with the inhibition of prostate cancer metastasis, implying that RKIP may be a potential clinical target as a suppressor of tumor metastasis through inhibition of vascular invasion.

General readings

Rath,O., (2008) Cell. Signal. 20 (5), 935-941

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PEBP1 / RKIP antibody

  Rabbit anti-PEBP1 Polyclonal Antibody  
Western blot analysis of testis cell and brian cell lysate,using PEBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEBP1 / RKIP (C-term) antibody

  Goat Polyclonal Antibody against PEBP1  
TA302567 staining (0.01µg/ml) of A549 lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEBP1 / RKIP antibody

  Goat Polyclonal Antibody against PEBP1 / RKIP (Internal)  
TA302568 (0.01µg/ml) staining of Human Prostate lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEBP1 / RKIP antibody

  Rabbit polyclonal PEBP1 antibody  
Western blot analysis of extracts from K562 cells and Jurkat cells, using PEBP1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PEBP1 / RKIP antibody

  Rabbit Polyclonal Anti-PEBP1 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-4: A549 cells, K562 cells, hela cells, hepG2 cells, Primary antibody: (PEBP1 Antibody) at dilution 1/475, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PEBP1 / RKIP antibody

  anti-PEBP1 (PBP) mouse monoclonal antibody, clone OTI2D4 (formerly 2D4)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PEBP1 (RC206355, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PEBP1. Mouse IgG1 OTI2D4 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PEBP1 / RKIP antibody

Figure 1. Western blot of rat brain lysate showing the specific immunolabeling of the ~22k PEBP protein. Rabbit IgG Serum Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

PEBP1 / RKIP (N-term) antibody

(TOP)Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.  (BUTTOM)Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PBP antibody (N-term) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PEBP1 / RKIP (Center) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PEBP1 / RKIP (175-187) antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PEBP1 antibody AP22528PU-N at 1.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Can, Chk, Eq, Fi, Hst, Hu, Insect, Mky, Ms, Op, Por, Prim, Rb, Tr, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PEBP1 / RKIP (70-83) antibody

Human Adrenal (formalin-fixed, paraffin-embedded) stained with PEBP1 antibody AP22542PU-N at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Can, Chk, Eq, Fi, Hst, Hu, Insect, Mky, Ms, Nematode, Op, Por, Prim, Rb, Rt, Tr, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PEBP1 / RKIP antibody

Western blot analysis of extracts from Jurkat/K562 cells, using PEBP1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

PEBP1 / RKIP antibody

Western blot analysis of extracts from Jurkat/K562 cells, using PEBP1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

PEBP1 - human gene knockout kit via CRISPR

PEBP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PEBP1 - human gene knockout kit via CRISPR

PEBP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PEBP1 - human gene knockout kit via CRISPR

PEBP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PEBP1 - human gene knockout kit via CRISPR

PEBP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pebp1 - mouse gene knockout kit via CRISPR

Pebp1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pebp1 - mouse gene knockout kit via CRISPR

Pebp1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pebp1 - mouse gene knockout kit via CRISPR

Pebp1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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