PELI2 antibody

Principal name

PELI2 antibody

Alternative names for PELI2 antibody

Protein pellino homolog 2, Pellino-2, Pellino 2

SwissProt ID

Q8BST6 (Mouse), Q9HAT8 (Human)

Gene ID

57161 (PELI2), 3571612 (aroB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PELI2 antibody

PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. It can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

General readings

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Ordureau, A., et al. Biochem. J. 409(1):43-52(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Liu, Y., et al. J. Biol. Chem. 279(36):37436-37444(2004)
Strelow, A., et al. FEBS Lett. 547 (1-3), 157-161 (2003)

7 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PELI2 (N-term) antibody

Western blot analysis of PELI2 Antibody (N-term) Cat.-No AP53254PU-N in 293 cell line lysates (35ug/lane). This demonstrates the PELI2 antibody detected the PELI2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PELI2 antibody

PELI2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PELI2 (1-420, His-tag)

PELI2 Human Purified > 80 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

PELI2 (1-420, His-tag)

PELI2 Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

PELI2

PELI2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PELI2

PELI2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PELI2 293T Cell Transient Overexpression Lysate(Denatured)

PELI2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

7 Item(s)

per page
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