PEN2 antibody

Principal name

PEN2 antibody

Alternative names for PEN2 antibody

PSENEN, MDS033, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2

SwissProt ID

Q5G235 (Bovin), Q6QI68 (Rat), Q9CQR7 (Mouse), Q9NZ42 (Human)

Gene ID

55851 (PSENEN), 66340 (Psenen), 292788

Available reactivities

Hu (Human), Hst (Hamster), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of PEN2 antibody

PEN2 (gamma-secretase subunit PEN-2 or presenilin enhancer protein 2) is an essential subunit of the gamma-secretase complex which is an endoprotease complex responsible for catalyzing the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Gamma-secretase complex is composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. PEN2 represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. PEN2 is a multi-pass membrane protein predomintly localized in the endoplasmic reticulum and in the Golgi stack membrane/cis-Golgi. Defects in PEN2 have been linked to familial acne inversa type 2 (ACNINV2), a chronic relapsing inflammatory disease of the hair follicles which is primarily characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PEN2 (N-term) antibody

Human Thymus (formalin-fixed, paraffin-embedded) stained with PSENEN antibody AP22868PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PEN2 (C-term) antibody

  Rabbit Polyclonal PEN2 Antibody  
Western blot analysis of PEN2 in K562 cell lysate with PEN2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEN2 (N-term) antibody

  Rabbit Polyclonal PEN2 Antibody  
Western blot analysis of PEN2 in A-20 cell lysate with PEN2 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEN2 antibody

  Rabbit Polyclonal PSENEN/PEN2 Antibody  
Western Blot: PEN2 Antibody [TA336624] - Analysis of PEN2 on human placenta. Rabbit Purified Hu, Ms IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PEN2 antibody

  Rabbit Polyclonal Anti-PSENEN Antibody  
WB Suggested Anti-PSENEN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PEN2 (C-term) antibody

Immunofluorescence of K562 cells with Rabbit anti PEN2 (AP01104PU-N) Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Psenen - mouse gene knockout kit via CRISPR

Psenen - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Psenen - mouse gene knockout kit via CRISPR

Psenen - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Psenen - mouse gene knockout kit via CRISPR

Psenen - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Psenen - mouse gene knockout kit via CRISPR

Psenen - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PEN2

  Recombinant protein of human presenilin enhancer 2 homolog (C. elegans) (PSENEN)  
PEN2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PSENEN overexpression lysate

PSENEN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Psenen (GFP-tagged ORF) - Rat presenilin enhancer 2 homolog (C. elegans) (Psenen), 200 uL, >10^7 TU/mL

Lenti ORF particles, Psenen (GFP-tagged ORF) - Rat presenilin enhancer 2 homolog (C. elegans) (Psenen), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Psenen (Myc-DDK-tagged ORF) - Rat presenilin enhancer 2 homolog (C. elegans) (Psenen), 200 uL, >10^7 TU/mL

Lenti ORF particles, Psenen (Myc-DDK-tagged ORF) - Rat presenilin enhancer 2 homolog (C. elegans) (Psenen), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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