PEN2 antibody

Principal name

PEN2 antibody

Alternative names for PEN2 antibody

PSENEN, MDS033, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2

SwissProt ID

Q5G235 (Bovin), Q6QI68 (Rat), Q9CQR7 (Mouse), Q9NZ42 (Human)

Gene ID

55851 (PSENEN), 66340 (Psenen)

Available reactivities

Hu (Human), Ms (Mouse), Hst (Hamster), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)

Background of PEN2 antibody

PEN2 (gamma-secretase subunit PEN-2 or presenilin enhancer protein 2) is an essential subunit of the gamma-secretase complex which is an endoprotease complex responsible for catalyzing the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Gamma-secretase complex is composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. PEN2 represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. PEN2 is a multi-pass membrane protein predomintly localized in the endoplasmic reticulum and in the Golgi stack membrane/cis-Golgi. Defects in PEN2 have been linked to familial acne inversa type 2 (ACNINV2), a chronic relapsing inflammatory disease of the hair follicles which is primarily characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PEN2 (N-term) antibody

Human Thymus (formalin-fixed, paraffin-embedded) stained with PSENEN antibody AP22868PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PEN2 (C-term) antibody

Western blot analysis of PEN2 in K562 cell lysate with PEN2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEN2 (N-term) antibody

Western blot analysis of PEN2 in A-20 cell lysate with PEN2 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PEN2 antibody

Western Blot: PEN2 Antibody [TA336624] - Analysis of PEN2 on human placenta. Rabbit Purified Hu, Ms IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PEN2 antibody

WB Suggested Anti-PSENEN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PEN2 (C-term) antibody

Immunofluorescence of K562 cells with Rabbit anti PEN2 (AP01104PU-N) Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

PEN2 Control Peptide

PEN2
50 µg / €160.00
  Acris Antibodies GmbH

PEN2 Control Peptide

PEN2
50 µg / €160.00
  Acris Antibodies GmbH

PEN2 antibody

PEN2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PEN2 antibody

Detection limit for recombinant GST tagged PSENEN is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 1C12-G5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PEN2 antibody

Western blot analysis in Rat brain homogenate ( 15 µg ) . Overnight incubation PVDF membrane with PSENEN polyclonal antibody ( Cat # PAB0141 ) ( 15 µg/ml ) in PBS containing 1% PBS. Horesradish peroxidase-conjugated anti-rabbit ( 0.5 µg/ml ; GE-Biosciences ) was used for detection. Rabbit Hst, Hu, Ms WB
0.2 mg / €640.00
  Abnova Taiwan Corp.

PEN2 antibody

Immunofluorescence of PSENEN in K-562 cells with PSENEN polyclonal antibody ( Cat # PAB13229 ) at 20 µg/ml. Rabbit Hu, Ms, Rt ICC/IF, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

PEN2 antibody

Immunohistochemistry of PSENEN in rat lung tissue with PSENEN polyclonal antibody ( Cat # PAB13230 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

PEN2 antibody

PEN2 Rabbit Aff - Purified Hst, Hu, Ms WB
0.1 mg / €370.00
  AgriSera AB

PEN2 (C-term) antibody

PEN2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

PEN2 (N-term) antibody

Mouse Heart; WB Suggested Anti-Psenen Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Heart; Psenen antibody - N-terminal region (ARP59440_P050) in Mouse Heart cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

PEN2 antibody

PEN2 Rabbit CR8 Serum Hu, Ms IP, WB
25 µl / €160.00
  Novus Biologicals Inc.

PEN2 antibody

Immunofluorescence: PEN2 Antibody [NBP1-77267] - K562 cells with PEN2 antibody at 20 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PEN2 antibody

Immunohistochemistry-Paraffin: PEN2 Antibody [NBP1-77268] - Rat lung tissue with PEN2 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PEN2

PEN2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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