PER1 antibody

Principal name

PER1 antibody

Alternative names for PER1 antibody

Period circadian protein homolog 1, hPER, Circadian clock protein PERIOD 1, PER, RIGUI, KIAA0482, Circadian pacemaker protein Rigui

SwissProt ID

O15534 (Human), O35973 (Mouse), Q8CHI5 (Rat)

Gene ID

5187 (PER1), 287422 (Per1), 18626

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of PER1 antibody

PER1 (Period, Drosophila, Homolog of), also known as PER or RIGUI, is a protein that in humans is encoded by the PER1 gene. By fluorescence in situ hybridization, Sun et al. (1997) mapped the human PER1 gene to 17p12. Sun et al. (1997) found that in mouse retina, the expression of rigui oscillated over a 24-hour period, with highest expression at onset of dark in a 12-hour light/dark cycle, i.e., expression rose during the light period and fell during the dark period. RNA abundance of rigui changed 2.9-fold between highest and lowest levels in mouse retina. Shigeyoshi et al. (1997) examined the effects of light on rigui, designated mouse Per1 by them, which exhibits robust rhythmic expression in the SCN. They found that Per1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock. Von Gall et al. (2002) demonstrated that cycling expression of the clock gene Per1 in rodent pituitary cells depends on the heterologous sensitization of the adenosine A2B receptor, which occurs through the nocturnal activation of melatonin mt1 receptors.

General readings

General / background references:Reppert SM A clockwork explosion! Neuron 21:1-4 (1998). PubMed PMID: 9697845
Gekakis N et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280:1564-9 (1998). PubMed PMID: 9616112
Darlington TK et al. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280:1599-603 (1998). PubMed PMID: 9616122

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PER1 antibody

Host: Rabbit; Target Name: PER1; Sample Tissue: Fetal Liver lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PER1 antibody

PER1 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PER1 (C-term) antibody

Western blot analysis of PER1 Antibody (C-term) Cat.-No AP53257PU-N in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PER1 antibody detected the PER1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PER1 antibody

Immunofluorescence of purified MaxPab antibody to PER1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

PER1 antibody

PER1 Rabbit Purified Rt WB
0.2 mg / €660.00
  Abnova Taiwan Corp.

PER1 antibody

PER1 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

PER1 antibody

PER1 Rabbit Aff - Purified Hu WB
0.2 mg / €630.00
  Funakoshi Co., Ltd.

PER1 antibody

PER1 Rabbit Aff - Purified Rt WB
0.2 mg / €630.00
  Funakoshi Co., Ltd.

PER1 antibody

PER1 Rabbit Aff - Purified Hu, Ms C, ICC/IF, P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

PER1 293T Cell Transient Overexpression Lysate(Denatured)

PER1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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