Perforin 1 / PRF1 antibody

Principal name

Perforin 1 / PRF1 antibody

Alternative names for Perforin 1 / PRF1 antibody

Perforin-1, Pore forming protein, PFN, PFP, Cytolysin, Lymphocyte pore-forming protein

SwissProt ID

P10820 (Mouse), P14222 (Human), P35763 (Rat)

Gene ID

5551 (PRF1), 18646 (Prf1), 15551 (Htr1b), 4747 (NEFL)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Chk (Chicken)

Available hosts

Mouse, Rabbit, Rat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), ELISA (capture) (E(capture))

Background of Perforin 1 / PRF1 antibody

Perforin is one of the major cytolytic proteins of cytolytic granules. One of the main pathways of lymphocyte mediated cytolysis entails the secretion onto target membranes of cytolytic granules contained in cytolytic effector lymphocytes of T cell or NK cell type. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Perforin is involved in the killing mediated by cytotoxic lymphocytes, which represents an important mechanism in the immune defense against tumors and virus infections. Human perforin is a 555 amino acid protein with a 21 amino acid signal peptide. It has a molecular weight of 70 to 75 kDa. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9 and homology between perforin and C9 has been demonstrated at their respective functionally conserved regions. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested.

General readings

Sanborn, K. B. et al., J. Immunol.,2009;182(11): 6969-6984

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Perforin 1 / PRF1 antibody

Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. Perforin 1 antibody. TA308615 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

Western blot analysis of Perforin in rat kidney glomerulars. Rabbit Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

Western blot analysis of extracts of various cell lines, using PRF1 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

Immunohistochemistry staining of Paraffin Spleen tissue by Perforin antibody (dilution: 1:10 - 1:50; visualization of staining: Perinuclear cytoplasmic) Mouse IgG1 MRQ-23 Purified Hu P
1 ml / €470.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG2b dG9 Purified Hu C, F, ICC/IF, IP
0.1 mg / €420.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG2b dG9 PE Bov, Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 (C-term) antibody

Perforin 1 / PRF1 Mouse IgG1 5B10 Supernatant Hu C, P
1 ml / €650.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 (C-term) antibody

Perforin 1 / PRF1 Mouse IgG1 5B10 Supernatant Hu C, P
0.5 ml / €420.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Formalin-Fixed, Paraffin-Embedded Human skin T/NK cell lymphoma stained with Perforin antibody Cat.-No. AM10133SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells. Mouse IgG1 MRQ-23 Supernatant Hu P
1 ml / €630.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG1 B-D48 Azide Free Hu C, F, WB
0.2 mg / €270.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG1 B-D48 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

A typical staining pattern on YT cell line (left) and on PBL (right) with B-D48 PerCP monoclonal antibody. Mouse IgG1 B-D48 PerCP F
1ml (100T) / €300.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Flow cytometric analysis of perforin in human YT-Indy cell line with the B-D48 monoclonal antibody Mouse IgG1 B-D48 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Flow cytometric analysis of perforin on YT-Indy cell line with the B-D48 monoclonal antibody Mouse IgG1 B-D48 PE Hu F
1ml (100T) / €290.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG2b B-E48 Azide Free Hu E(capture), Elispot
1 mg / €790.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG1 B-D48 Biotin Hu E(detection), Elispot
0.1 mg / €460.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Western Blot analysis of PRF1 expression in transfected 293T cell line (H00005551-T02) by PRF1 MaxPab polyclonal antibody.

Lane 1: PRF1 transfected lysate(61.05 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Perforin 1 / PRF1 antibody

Western Blot analysis of PRF1 expression in transfected 293T cell line (H00005551-T02) by PRF1 MaxPab polyclonal antibody.

Lane 1: PRF1 transfected lysate(61.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Perforin 1 / PRF1 antibody

Western Blot analysis of PRF1 expression in transfected 293T cell line by PRF1 monoclonal antibody (M04), clone 3B4.

Lane 1: PRF1 transfected lysate(61.4 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 3B4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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