Perforin 1 / PRF1 antibody

Principal name

Perforin 1 / PRF1 antibody

Alternative names for Perforin 1 / PRF1 antibody

Perforin-1, Pore forming protein, PFN, PFP, Cytolysin, Lymphocyte pore-forming protein

SwissProt ID

P10820 (Mouse), P14222 (Human), P35763 (Rat)

Gene ID

5551 (PRF1), 18646 (Prf1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Rat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), ELISA (capture) (E(capture))

Background of Perforin 1 / PRF1 antibody

PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

General readings

Sanborn, K. B. et al., J. Immunol.,2009;182(11): 6969-6984

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Perforin 1 / PRF1 antibody

  Rabbit polyclonal antibody to Perforin 1 (perforin 1 (pore forming protein))  
Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. Perforin 1 antibody. TA308615 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

  PRF1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PRF1 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

  Mouse Monoclonal Perforin Antibody  
Immunohistochemistry staining of Paraffin Spleen tissue by Perforin antibody (dilution: 1:10 - 1:50; visualization of staining: Perinuclear cytoplasmic) Mouse IgG1 MRQ-23 Purified Hu P
1 ml / €760.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

  Rabbit Polyclonal Anti-PRF1 Antibody  
WB Suggested Anti-PRF1 Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG2b dG9 Purified Hu C, F, ICC/IF, IP
0.1 mg / €380.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG2b dG9 PE Bov, Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 (C-term) antibody

Perforin 1 / PRF1 Mouse IgG1 5B10 Supernatant Hu C, P
1 ml / €670.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 (C-term) antibody

Perforin 1 / PRF1 Mouse IgG1 5B10 Supernatant Hu C, P
0.5 ml / €430.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Formalin-Fixed, Paraffin-Embedded Human skin T/NK cell lymphoma stained with Perforin antibody Cat.-No. AM10133SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells. Mouse IgG1 MRQ-23 Supernatant Hu P
1 ml / €640.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG1 B-D48 Azide Free Hu C, F, WB
0.2 mg / €270.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG1 B-D48 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

A typical staining pattern on YT cell line (left) and on PBL (right) with B-D48 PerCP monoclonal antibody. Mouse IgG1 B-D48 PerCP F
1ml (100T) / €300.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Flow cytometric analysis of perforin in human YT-Indy cell line with the B-D48 monoclonal antibody Mouse IgG1 B-D48 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Flow cytometric analysis of perforin on YT-Indy cell line with the B-D48 monoclonal antibody Mouse IgG1 B-D48 PE Hu F
1ml (100T) / €290.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG2b B-E48 Azide Free Hu E(capture), Elispot
1 mg / €790.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Mouse IgG1 B-D48 Biotin Hu E(detection), Elispot
0.1 mg / €460.00
  Acris Antibodies GmbH

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Rabbit Purified Ms, Rt WB
0.2 mg / €290.00
  Torrey Pines Biolabs

Perforin 1 / PRF1 antibody

Perforin 1 / PRF1 Rabbit Azide Free Ms, Rt WB
0.2 mg / €290.00
  Torrey Pines Biolabs

CRISPR

Catalog No. Species Donor Vector  

PRF1 - human gene knockout kit via CRISPR

PRF1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PRF1 - human gene knockout kit via CRISPR

PRF1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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