Perilipin-1 antibody

Principal name

Perilipin-1 antibody

Alternative names for Perilipin-1 antibody

Perilipin, PLIN, PLIN1, PLIN-1, PERI, Lipid Droplet-Associated Protein

SwissProt ID

O60240 (Human), P43884 (Rat), Q8CGN5 (Mouse)

Gene ID

25629 (Plin1), 5346 (PLIN1), 103968

Available reactivities

Ms (Mouse), Rt (Rat), Bov (Bovine), Hu (Human), Por (Porcine), Sh (Sheep), Can (Canine), Chk (Chicken), Ze (Zebrafish)

Available hosts

Rabbit, Guinea Pig, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of Perilipin-1 antibody

Perilipins, members of the PAT protein family (named after lipid droplet proteins Perilipin, Adipophilin, and TIP47) are found exclusively at the surface of lipid droplets in adipocytes and steroidogenic cells. They have been suggested to function as regulators of lipolysis and triacylglycerol storage within adipose tissue. Four distinct isoforms ranging from perilipin A (57 kDa) to perilipin D (26 kDa) have been identified and they share an identical amino terminal sequences, and contain 2–6 consensus protein kinase A (PKA) phosphorylation sites. Perilipin C and D have been detected only in steroidogenic cells. Perilipin A is the most abundant form on the lipid droplets of adipocytes. The phosphorylation of perilipin by PKA, which is accompanied by the phosphorylation and translocation of hormone-sensitive lipase from the cytosol to the lipid droplets, promotes lipolysis. There is evidence for the presence of perilipin A in atheroma plaques suggesting that the protein may be involved in the development of therosclerosis by controlling as in adipocytes the hydrolysis of stored lipids.
Adipose tissue is an energy reserve in animals and is strictly regulated in nondomestic species. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), resistin, and Perilipin. Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, Perilipin is phosphorylated by protein kinase A. Once activated, Perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body.
Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.

General readings

Wolins NE, Brasaemle DL, Bickel PE.
A proposed model of fat packaging by exchangeable lipid droplet proteins.
FEBS Lett. 2006 Oct 9;580(23):5484-91. Epub 2006 Sep 1. Review.
PMID: 16962104

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Perilipin-1 antibody

Perilipin-1 Guinea Pig Serum Bov, Hu, Ms, Rt C, P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Perilipin-1 antibody

TA303218 (0.01µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Perilipin-1 (C-term) antibody

TA303219 (0.01µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Perilipin-1 antibody

Western Blot: Perilipin Antibody -WB detection of Perilipin in human liver samples. Rabbit Purified Bov, Hu, Ms, Por, Rt, Sh WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Perilipin-1 antibody

Western blot analysis of Perilipin A in Jurkat cell lysate. Rabbit Purified Hu, Ms, Rt WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

Perilipin-1 antibody

Perilipin-1 Mouse IgG1 PERI112.17 Supernatant Bov, Hu, Ms, Rt C, ICC/IF, P, WB
5 ml / €290.00
  Acris Antibodies GmbH

Perilipin-1 (488-499) antibody

Human Colon (formalin-fixed, paraffin-embedded) stained with PLIN antibody AP22521PU-N at 2 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Perilipin-1 (C-term) antibody

Human Colon (formalin-fixed, paraffin-embedded) stained with PLIN antibody AP22522PU-N at 4 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Purified Can, Hu, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Perilipin-1 (C-term) antibody

Perilipin-1 Guinea Pig Serum Bov, Hu C, P, WB
0.1 ml / €370.00
  Acris Antibodies GmbH

Perilipin-1 antibody

PLIN MaxPab rabbit polyclonal antibody. Western Blot analysis of PLIN expression in human kidney. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Perilipin-1 antibody

Detection limit for recombinant GST tagged PLIN is approximately 3ng/ml as a capture antibody. Mouse IgG2a 4G1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Perilipin-1 antibody

PLIN polyclonal antibody ( Cat # PAB7249 ) ( 0.01 µg/ml ) staining of human adipose lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Perilipin-1 antibody

PLIN polyclonal antibody ( Cat # PAB7250 ) staining of differentiated 3T3-L1 adipocytes. Data kindly provided by Prof. J. Granneman, Detroit, USA Goat Hu E, ICC/IF, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Perilipin-1 antibody

Western blot analysis of PLIN1 in human liver samples with PLIN1 polyclonal antibody ( Cat# PAB12071 ). Rabbit Bov, Hu, Ms, Rt, Sh WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

Perilipin-1 antibody

Human Jurkat; WB Suggested Anti-PLIN Antibody Titration: 1.25ug/ml. Positive Control: Jurkat cell lysate; PLIN antibody - N-terminal region (ARP42057_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Perilipin-1 (transcript variant 1)

Perilipin-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Perilipin-1

Perilipin-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Perilipin-1

Perilipin-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PLIN1 overexpression lysate

PLIN1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

PLIN1 overexpression lysate

PLIN1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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