Peroxiredoxin-1 / PRDX1 antibody

Principal name

Peroxiredoxin-1 / PRDX1 antibody

Alternative names for Peroxiredoxin-1 / PRDX1 antibody

PRDX-1, Prx1, Prx-1, PAG, NKEF-A, NKEFA PAGA, PAGB, TDPX2, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Proliferation-associated gene protein, Natural killer cell-enhancing factor A

SwissProt ID

P35700 (Mouse), Q06830 (Human), Q5E947 (Bovin), Q63716 (Rat)

Gene ID

5052 (PRDX1), 18477 (Prdx1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Bt (Bat), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Peroxiredoxin-1 / PRDX1 antibody

PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

General readings

1. Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T.,
Fujiwara, Y., Orkin, S. H., Van Etten, R. A.Essential role for the peroxiredoxin Prdx1 in erythrocyte
antioxidant defence and tumour suppression. Nature 424: 561-565, 2003.
2. Prosperi, M.-T., Apiou, F., Dutrillaux, B., Goubin, G. Organization and chromosomal assignment of
two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed
pseudogene. Genomics 19: 236-241, 1994.
3. Yan, Y., Sabharwal, P., Rao, M., Sockanathan, S. The antioxidant enzyme Prdx1 controls neuronal
differentiation by thiol-redox-dependent activation of GDE2. Cell 138: 1209-1221, 2009.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Peroxiredoxin-1 / PRDX1 antibody

  Goat Anti-PRDX1 Antibody  
TA305773 (0.01ug/ml) staining of HepG2 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

  Anti-PRDX1 Rabbit Polyclonal Antibody  
Predicted band size: 22 kDa . Positive control: Mouse liver tissue, NIH/3T3, RAW264.7, 293T, K562, Jurkat and Hela cell lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

  Anti-PRDX1 Rabbit Polyclonal Antibody  
Predicted band size: 22 kDa . Positive control: Mouse liver, kidney and Human fetal brain tissue, NIH/3T3, RAW264.7, 293T, K562, Jurkat and Hela cell lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

  Rabbit anti-PRDX1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PRDX1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

Western blot analysis: Cell lysates of HeLa (40 µg) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PRDX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT1D8 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 antibody

Western blot analysis: Cell lysates of HeLa (40 µg) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PRDX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT1D8 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 (Center) antibody

(LEFT) Western blot analysis of PRDX1 Antibody (Center) (AP17660PU-N) in CEM cell line lysates (35ug/lane). PRDX1 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of PRDX1 (arrow) using rabbit polyclonal PRDX1 Antibody (Center) (AP17660PU-N). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRDX1 gene (Lane 2) . Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 (106-117) antibody

Immunohistochemistry: Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PRDX1 - human gene knockout kit via CRISPR

PRDX1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PRDX1 - human gene knockout kit via CRISPR

PRDX1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDX1 - human gene knockout kit via CRISPR

PRDX1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDX1 - human gene knockout kit via CRISPR

PRDX1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prdx1 - mouse gene knockout kit via CRISPR

Prdx1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Prdx1 - mouse gene knockout kit via CRISPR

Prdx1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prdx1 - mouse gene knockout kit via CRISPR

Prdx1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prdx1 - mouse gene knockout kit via CRISPR

Prdx1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Peroxiredoxin-1 / PRDX1 (transcript variant 3)

  Recombinant protein of human peroxiredoxin 1 (PRDX1), transcript variant 3  
Peroxiredoxin-1 / PRDX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 (transcript variant 1)

  Recombinant protein of human peroxiredoxin 1 (PRDX1), transcript variant 1  
Peroxiredoxin-1 / PRDX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 (transcript variant 2)

  Recombinant protein of human peroxiredoxin 1 (PRDX1), transcript variant 2  
Peroxiredoxin-1 / PRDX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 (1-199, His-tag)

Recombinant human Peroxiredoxin (aa 1-199), His-tagged: 15% SDS-PAGE (3 µg). Human Purified > 90 % by SDS PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

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