Peroxiredoxin-1 / PRDX1 antibody

Principal name

Peroxiredoxin-1 / PRDX1 antibody

Alternative names for Peroxiredoxin-1 / PRDX1 antibody

PRDX-1, Prx1, Prx-1, PAG, NKEF-A, NKEFA PAGA, PAGB, TDPX2, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Proliferation-associated gene protein, Natural killer cell-enhancing factor A

SwissProt ID

P35700 (Mouse), Q06830 (Human), Q5E947 (Bovin), Q63716 (Rat)

Gene ID

5052 (PRDX1)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Chk (Chicken), Ze (Zebrafish), Hst (Hamster)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunoprecipitation (IP), Dot blot (Dot)

Background of Peroxiredoxin-1 / PRDX1 antibody

PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

General readings

1. Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T.,
Fujiwara, Y., Orkin, S. H., Van Etten, R. A.Essential role for the peroxiredoxin Prdx1 in erythrocyte
antioxidant defence and tumour suppression. Nature 424: 561-565, 2003.
2. Prosperi, M.-T., Apiou, F., Dutrillaux, B., Goubin, G. Organization and chromosomal assignment of
two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed
pseudogene. Genomics 19: 236-241, 1994.
3. Yan, Y., Sabharwal, P., Rao, M., Sockanathan, S. The antioxidant enzyme Prdx1 controls neuronal
differentiation by thiol-redox-dependent activation of GDE2. Cell 138: 1209-1221, 2009.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Peroxiredoxin-1 / PRDX1 antibody

Human Brain; Researcher: Dr. Yuzhi Chen, University of Arkansas for Medical Science. Application: IHC. Species+tissue/cell type: Human brain stem cells. Primary antibody dilution: 1:500. Secondary antibody: Goat anti-rabbit Alexa-Fluor 594. Secondary antibody dilution: 1:1000; PRDX1 antibody - N-terminal region (ARP48454_P050) in Human Brain cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Peroxiredoxin-1 / PRDX1 antibody

Immunohistochemistry-Paraffin: Peroxiredoxin 1 Antibody (EPR5433) [NBP1-95676] - Peroxiredoxin 1. Rabbit EPR5433 Purified Hu, Ms F, ICC/IF, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Peroxiredoxin-1 / PRDX1 antibody

TA305773 (0.01ug/ml) staining of HepG2 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

Predicted band size: 22 kDa . Positive control: Mouse liver tissue, NIH/3T3, RAW264.7, 293T, K562, Jurkat and Hela cell lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

Predicted band size: 22 kDa . Positive control: Mouse liver, kidney and Human fetal brain tissue, NIH/3T3, RAW264.7, 293T, K562, Jurkat and Hela cell lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

Western blot analysis of extracts of various cell lines, using PRDX1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-1 / PRDX1 antibody

Western blot analysis: Cell lysates of HeLa (40 µg) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PRDX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT1D8 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 antibody

Western blot analysis: Cell lysates of HeLa (40 µg) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PRDX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT1D8 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 (Center) antibody

(LEFT) Western blot analysis of PRDX1 Antibody (Center) (AP17660PU-N) in CEM cell line lysates (35ug/lane). PRDX1 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of PRDX1 (arrow) using rabbit polyclonal PRDX1 Antibody (Center) (AP17660PU-N). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRDX1 gene (Lane 2) . Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 (106-117) antibody

Immunohistochemistry: Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Peroxiredoxin-1 / PRDX1 antibody

Peroxiredoxin-1 / PRDX1 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

PRDX1 monoclonal antibody (M01), clone 4B11-D10 Western Blot analysis of PRDX1 expression in HeLa ( Cat # L013V1 ). Mouse IgG1 4B11-D10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Immunocytochemical staining of human Hela cells using PRDX1 monoclonal antibody, clone 9D2 ( Cat # PAB0690 ) . Mouse IgG1 9D2 Hu ICC/IF, IP
0.1 ml / €390.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Immunoprecipitation analysis of Hela cell lysates. Lane 1 : Input and lane 2 : Precipitates. Mouse IgG1 2A4 Hu IP
0.1 ml / €390.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Immunoprecipitation analysis of Hela cell lysates. Lane 1 : Input and lane 2 : Precipitates. Mouse IgG1 13E7 Hu E, IP
0.1 ml / €390.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Immunoblot analysis of cell lysates. Lane 1 : HeLa cell lysate. Lane 2 : A-431 cell lysate. Lane 3 : HL-60 cell lysate. Lane 4 : SK-N-MC cell lysate. Mouse IgG1 3G5 Hu E, IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Immunoblot analysis of cell lysates.
Lane 1 : HeLa cell lysate.
Lane 2 : A-431 cell lysate.
* For Western blots, incubate membrane with diluted antibody in 5% w/v BSA , 1X TBS , 0.1% Tween-20 at 4°C with gentle shaking , overnight. Rabbit Hu WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Peroxiredoxin-1 / PRDX1 Rabbit Hu WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

PRDX1 polyclonal antibody ( Cat # PAB11441 ) ( 0.01 µg/ml ) staining of HepG2 lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Peroxiredoxin-1 / PRDX1 antibody

Peroxiredoxin-1 / PRDX1 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

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