Peroxiredoxin-4 / PRDX4 antibody

Principal name

Peroxiredoxin-4 / PRDX4 antibody

Alternative names for Peroxiredoxin-4 / PRDX4 antibody

PRDX-4, Prx4, Prx-4, Prx-IV, AOE37-2, Thioredoxin peroxidase AO372,Thioredoxin-dependent peroxide reductase A0372, Antioxidant enzyme AOE372

SwissProt ID

O08807 (Mouse), Q13162 (Human), Q9BGI2 (Bovin)

Gene ID

10549 (PRDX4), 53381 (Prdx4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E), Frozen Sections (C)

Background of Peroxiredoxin-4 / PRDX4 antibody

PRDX4(peroxiredoxin 4) also known as AOE37-2. The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. Functional analysis showed that PRDX4 protects glutamine synthetase from inactivation. Yeast 2-hybrid, immunoprecipitation, and immunoblot analyses indicated that PRDX4 and PRDX1 are capable of homodimerization and heterodimerization with each other but not with the mitochondrial PRDX3. Gel mobility shift and immunoblot analysis found that PRDX4 depletes NFKB binding activity together with a reduction in the amounts of p50, p65, and phosphorylated IKBA, as well as a reduction in the expression of HIV-1 viral proteins. Expression of PRDX4, alone or with PRDX1, increased the resistance of yeast cells to oxidant-induced toxicity. Jin et al. (1997)suggested PRDX4 modulates IKBA phosphorylation in the cytoplasm and thus affects a peroxiredoxin-dependent redox step.

General readings

Wang HQ., et al. (2009) FEBS Lett. 583(9):1511-5.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Peroxiredoxin-4 / PRDX4 antibody

  PRDX4 (Peroxiredoxin 4) mouse monoclonal antibody, clone OTI9A3 (formerly 9A3)  
Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PRDX4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500684) Mouse IgG1 OTI9A3 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Peroxiredoxin-4 / PRDX4 (Center) antibody

PRDX4 Antibody (Center) (Cat. #AP53439PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRDX4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Peroxiredoxin-4 / PRDX4 antibody

  Anti-PRDX4 Rabbit Polyclonal Antibody  
Predicted band size: 31 kDa . Positive control: HepG2 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-4 / PRDX4 antibody

  Rabbit anti-PRDX4 Polyclonal Antibody  
Western blot analysis of extracts of variouscell lines, using PRDX4 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-4 / PRDX4 antibody

  Rabbit Polyclonal Anti-PRDX4 Antibody  
Host: Rabbit; Target Name: PRDX4; Sample Tissue: COLO205 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml PRDX4 is supported by BioGPS gene expression data to be expressed in COLO205 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Peroxiredoxin-4 / PRDX4 antibody

  Rabbit Polyclonal Anti-PRDX4 Antibody  
WB Suggested Anti-PRDX4 Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

PRDX4 - human gene knockout kit via CRISPR

PRDX4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PRDX4 - human gene knockout kit via CRISPR

PRDX4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDX4 - human gene knockout kit via CRISPR

PRDX4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDX4 - human gene knockout kit via CRISPR

PRDX4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prdx4 - mouse gene knockout kit via CRISPR

Prdx4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Prdx4 - mouse gene knockout kit via CRISPR

Prdx4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prdx4 - mouse gene knockout kit via CRISPR

Prdx4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prdx4 - mouse gene knockout kit via CRISPR

Prdx4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Peroxiredoxin-4 / PRDX4

  Recombinant protein of human peroxiredoxin 4 (PRDX4)  
Peroxiredoxin-4 / PRDX4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Peroxiredoxin-4 / PRDX4

  Recombinant protein of human peroxiredoxin 4 (PRDX4)  
Peroxiredoxin-4 / PRDX4 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

Peroxiredoxin-4 / PRDX4 (38-271, His-tag)

Peroxiredoxin-4 / PRDX4 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

Peroxiredoxin-4 / PRDX4 (38-271, His-tag)

Peroxiredoxin-4 / PRDX4 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PRDX4 (mGFP-tagged) - Human peroxiredoxin 4 (PRDX4), 200 uL, >10^7 TU/mL

Lenti ORF particles, PRDX4 (mGFP-tagged) - Human peroxiredoxin 4 (PRDX4), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, PRDX4 (Myc-DDK tagged) - Human peroxiredoxin 4 (PRDX4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PRDX4 (Myc-DDK tagged) - Human peroxiredoxin 4 (PRDX4) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

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