PEX5L antibody

Principal name

PEX5L antibody

Alternative names for PEX5L antibody

PEX5-related protein, PEX2-related protein, PEX5-like protein, Peroxin-5-related protein, Pex5Rp, PEX5R, PXR2, TRIP8b, Peroxisome biogenesis factor 5-like

SwissProt ID

Q8C437 (Mouse), Q8C437-3, Q8IYB4 (Human), Q925N3 (Rat)

Gene ID

58869 (Pex5l), 51555 (PEX5L), 286937

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PEX5L antibody

PEX5R (also called TRIP8b, tetratricopetide repeat-containing Rab8b-interacting protein) is a cytoplasmic protein expressed as a family of altertively spliced isoforms. PEX5R /TRIP8b isoforms contain a large constant domain preceded by a variable region. The C-termil half of TRIP8b comprises a tetratricopeptide repeat (TPR) protein binding domain. Alysis of the Pex5p-like protein revealed the presence of a tetratricopeptide repeat (TPR) domain in its C-termil half consisting of seven TPR motifs. Pex5R is almost exclusively expressed in brain. Recent studies provide strong evidence that PEX5R interacts with the carboxyl-termil region of Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and regulates their cell-surface expression level and cyclic nucleotide dependence. HCN channels are key modulators of neurol activity by providing the depolarizing cation current involved in rhythmogenesis, dendritic integration, and syptic transmission. In contrast, Gosh et al. have shown that human PEX5R can bind to peroxisomal targeting sigl-1 (PTS1) ligands. Furthermore it was shown that enzyme alanine–glyoxylate aminotransferase (AGT) is recognized by PEX5R in the cytoplasm, which allows its subsequent translocation into the peroxisome. TRIP8b may play a role in both normal neurol function and in aberrant neurol excitability associated with neurological diseases.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PEX5L antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N212/3 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PEX5L antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 N212/3 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PEX5L antibody

Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates: 1-2. Anti-TRIP8b antibody , (1:400). 3-4. Anti-TRIP8b antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

PEX5L antibody

WB Suggested Anti-Pex2 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Liver Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

PEX5L (constant) antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2b N212/7 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PEX5L (constant) antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a N212/17 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PEX5L (exon 1b) antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged TRIP8b-1a-4, TRIP8b-1b-2, TRIP8b-1a-2 or untagged Kv2.1 plasmid and probed with N212A/34 (left) or N86/8 (right) TC supe. Mouse IgG1 N212A/34 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PEX5L (exon 1a/5 junction) antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with carboxyterminally (C) and amino-terminally (N) GFP-tagged TRIP8b-1a-5, TRIP8b-1a-4 or untagged Kv2.1 plasmid and probed with N291C/22 (left)
and N212/7 (right) TC supe. 

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and TRIP8b KO mouse brains probed with N291C/22 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Dane Chetkovich (Northwestern University) Mouse IgG1 N291C/22 Supernatant Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

PEX5L (constant) antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2b N212/7 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PEX5L (constant) antibody

Adult rat hippocampus immunohistochemistry Mouse IgG2a N212/17 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PEX5L (exon 1b) antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged TRIP8b-1a-4, TRIP8b-1b-2, TRIP8b-1a-2 or untagged Kv2.1 plasmid and probed with N212A/34 (left) or N86/8 (right) TC supe. Mouse IgG1 N212A/34 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PEX5L (exon 1a/5 junction) antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with carboxyterminally (C) and amino-terminally (N) GFP-tagged TRIP8b-1a-5, TRIP8b-1a-4 or untagged Kv2.1 plasmid and probed with N291C/22 (left)
and N212/7 (right) TC supe. 

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and TRIP8b KO mouse brains probed with N291C/22 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Dane Chetkovich (Northwestern University) Mouse IgG1 N291C/22 Purified Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

PEX5L (C-term) antibody

Mouse Liver; WB Suggested Anti-Pex2 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Liver; Pex2 antibody - C-terminal region (ARP56944_P050) in Mouse Liver cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

PEX5L Common antibody

PEX5L Mouse IgG2b H0502 Purified Hu ELISA, WB
0.1 ml / €640.00
  Funakoshi Co., Ltd.

PEX5L antibody

PEX5L Rabbit Aff - Purified Hu, Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PEX5L

PEX5L Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

16 Item(s)

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