PFKFB1 antibody

Principal name

PFKFB1 antibody

Alternative names for PFKFB1 antibody

F6PK, PFRX, PFK/FBPase 1, PFK-2 liver, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

SwissProt ID

P07953 (Rat), P16118 (Human), P49872 (Bovin), P70266 (Mouse)

Gene ID

5207 (PFKFB1), 18639 (Pfkfb1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Mky (Monkey), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of PFKFB1 antibody

PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) is a bifunctional enzyme, having both kinase and phosphatase activities residing on the same enzyme subunit but having distinct active sites. PFKFB regulates the steady-state concentration of fructose-2,6-bisphosphate, a potent activator of a key regulatory enzyme of glycolysis, phosphofructokinase. To date, four PFKFB isozymes (PFKFB 1-4) have been described, which show differences in their tissue distribution and kinetic properties in response to allosteric effectors and hormonal signals. Among the PFKFB's PFKFB3 has the highest kinase:phosphatase ratio, in part because it lacks the characteristic serine phosphorylation site near the N-terminal that down-modulates kinase activity. PFKFB3 was first described in the rapidly growing placenta. The glucolitic rate in placenta is accelerated by anoxia and by maternal diabetes. Cancer cells maintain a high glycolytic rate even in the presence of oxygen, a phenomenon known as the Warburg effect. The glycolytic rate in the placenta, another fast-growing tissue, is accelerated by anoxia and by maternal diabetes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PFKFB1 antibody

Western blot analysis of extracts from HUVEC cells and Jurkat cells, using PFKFB1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PFKFB1 antibody

Western blot analysis of extracts from HeLa cells, HepG2 cells, COLO205 cells and 293 cells, using PFKFB1/4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PFKFB1 antibody

PFKFB1 Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PFKFB1 antibody

PFKFB1 Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PFKFB1 (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PFKFB1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PFKFB1 (Center) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PFKFB1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PFKFB1 (Liver) antibody

Immunohistochemistry: AP20411PU-N PFK-2 liv antibody staining of Paraffin-Embedded Human liver carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PFKFB1 antibody

PFKFB1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PFKFB1 antibody

Western Blot analysis of PFKFB1 expression in transfected 293T cell line (H00005207-T01) by PFKFB1 MaxPab polyclonal antibody.

Lane 1: PFKFB1 transfected lysate(51.81 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PFKFB1 antibody

PFKFB1 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PFKFB1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PFKFB1 polyclonal antibody ( Cat # PAB4020 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PFKFB1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PFKFB1 polyclonal antibody ( Cat # PAB4021 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PFKFB1 antibody

Western blot analysis of extracts from HeLa/HepG2/COLO205/293 cells, using PFKFB1/4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

PFKFB1/4 antibody

Western blot (WB) analysis of PFKFB1/4 antibody (Cat.-No.: AP06742PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PFKFB1/4 antibody

Western blot analysis of extracts from HeLa/HepG2/COLO205/293 cells, using PFKFB1/4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

PFKFB1/4 antibody

Western blot analysis of PFKFB1/4 expression in Jurkat (A); H1299 (B); HeLa (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Rt, Ze IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PFKFB1/4 antibody

Western blot analysis of PFKFB1/4 expression in Jurkat (A); H1299 (B); HeLa (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Rt, Ze IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PFKFB1/4 antibody

Western blot analysis of PFKFB1/4 expression in Jurkat (A); H1299 (B); HeLa (C) whole cell lysates. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Rt, Ze IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CRISPR

Catalog No. Species Donor Vector  

PFKFB1 - human gene knockout kit via CRISPR

PFKFB1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PFKFB1 - human gene knockout kit via CRISPR

PFKFB1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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