PGL2 / SDHAF2 antibody

Principal name

PGL2 / SDHAF2 antibody

Alternative names for PGL2 / SDHAF2 antibody

SDH assembly factor 2, SDH, C11orf79, Succinate dehydrogenase assembly factor 2 mitochondrial, Succinate dehydrogenase subunit 5 mitochondrial

SwissProt ID

A3KP74 (Danre), Q08230 (Yeast), Q3ZBC2 (Bovin), Q5RJQ7 (Rat), Q8C6I2 (Mouse), Q9NX18 (Human)

Gene ID

54949 (SDHAF2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Chicken, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of PGL2 / SDHAF2 antibody

SDHAF2 is a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Defects in SDHAF2 are the cause of hereditary paragangliomas type 2 (PGL2), also known as familial non-chromaffin paragangliomas type 2. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system.

General readings

Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 2009; 325:1139-42.
Burnichon N, Brière JJ, Libé R, et al. SDHA is a tumor suppressor gene causing paraganglioma. Hum. Mol. Genet. 2010; 19:3011-20.
Kunst HP, Rutten MH, de Monnink JP, et al. SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma. Clin. Cancer Res. 2011; 17:247-54. 
Starker LF, Delgado-Verdugo A, Udelsman R, et al. Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism. Endocrine 2010; 38:397-401.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PGL2 / SDHAF2 (N-term) antibody

Western blot analysis of SDHAF2 in rat liver tissue lysate with SDHAF2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Chicken Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PGL2 / SDHAF2 (N-term) Control Peptide

Western blot analysis in rat liver tissue lysate with PGL2 / SDHAF2 antibody Cat.-No. AP55591PU-N at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
50 µg / €160.00
  Acris Antibodies GmbH

PGL2 / SDHAF2 antibody

PGL2 / SDHAF2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

PGL2 / SDHAF2 antibody

Immunohistochemistry-Paraffin: PGL2 Antibody [NBP1-92259] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

PGL2 / SDHAF2 antibody

Immunohistochemistry-Paraffin: PGL2 Antibody [NBP1-92260] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PGL2 / SDHAF2

PGL2 / SDHAF2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PGL2 / SDHAF2 (30-166, His-tag)

PGL2 / SDHAF2 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

PGL2 / SDHAF2 (30-166, His-tag)

PGL2 / SDHAF2 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

SDHAF2 overexpression lysate

SDHAF2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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