PHAX / RNUXA antibody

Principal name

PHAX / RNUXA antibody

Alternative names for PHAX / RNUXA antibody

Phosphorylated adapter RNA export protein, RNA U small nuclear RNA export adapter protein

SwissProt ID

Q3MHI4 (Bovin), Q5ZLY0 (Chick), Q63068 (Rat), Q9H814 (Human), Q9JJT9 (Mouse)

Gene ID

51808 (PHAX)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of PHAX / RNUXA antibody

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

General readings

Mourao, A., et al. RNA 16(6):1205-1216(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lemm, I., et al. Mol. Biol. Cell 17(7):3221-3231(2006)
Watkins, N.J., et al. Mol. Cell 16(5):789-798(2004)
Boulon, S., et al. Mol. Cell 16(5):777-787(2004)

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PHAX / RNUXA antibody

Western blot analysis of extracts from HT-29 cells, using RNUXA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PHAX / RNUXA antibody

WB Suggested Anti-PHAX Antibody; Titration: 1.0 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PHAX / RNUXA antibody

Host: Rabbit; Target Name: PHAX; Sample Tissue: Fetal Liver lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PHAX / RNUXA (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with PHAX Antibody (C-term) Cat.-No AP53277PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of PHAX Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PHAX / RNUXA antibody

Western blot analysis of extracts from HT-29 cells, using RNUXA Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

PHAX / RNUXA antibody

Western blot analysis of extracts from HT-29 cells, using RNUXA Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

PHAX / RNUXA antibody

PHAX / RNUXA Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

PHAX / RNUXA antibody

PHAX / RNUXA Rabbit IgG Aff - Purified Hu E, WB
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PHAX / RNUXA

PHAX / RNUXA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PHAX / RNUXA

PHAX / RNUXA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

10 Item(s)

per page
  • LinkedIn