PHAX / RNUXA antibody

Principal name

PHAX / RNUXA antibody

Alternative names for PHAX / RNUXA antibody

Phosphorylated adapter RNA export protein, RNA U small nuclear RNA export adapter protein

SwissProt ID

Q3MHI4 (Bovin), Q5ZLY0 (Chick), Q63068 (Rat), Q9H814 (Human), Q9JJT9 (Mouse)

Gene ID

51808 (PHAX), 56698 (Phax), 286917

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PHAX / RNUXA antibody

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

General readings

Mourao, A., et al. RNA 16(6):1205-1216(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lemm, I., et al. Mol. Biol. Cell 17(7):3221-3231(2006)
Watkins, N.J., et al. Mol. Cell 16(5):789-798(2004)
Boulon, S., et al. Mol. Cell 16(5):777-787(2004)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PHAX / RNUXA antibody

  Rabbit polyclonal anti-RNUXA / PHAX antibody  
Western blot analysis of extracts from HT-29 cells, using RNUXA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PHAX / RNUXA antibody

  Rabbit Polyclonal Anti-PHAX Antibody  
WB Suggested Anti-PHAX Antibody; Titration: 1.0 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PHAX / RNUXA antibody

  Rabbit Polyclonal Anti-PHAX Antibody  
Host: Rabbit; Target Name: PHAX; Sample Tissue: Fetal Liver lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PHAX / RNUXA (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with PHAX Antibody (C-term) Cat.-No AP53277PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of PHAX Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PHAX / RNUXA antibody

Western blot analysis of extracts from HT-29 cells, using RNUXA Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

PHAX / RNUXA antibody

Western blot analysis of extracts from HT-29 cells, using RNUXA Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Phax - mouse gene knockout kit via CRISPR

Phax - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Phax - mouse gene knockout kit via CRISPR

Phax - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Phax - mouse gene knockout kit via CRISPR

Phax - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Phax - mouse gene knockout kit via CRISPR

Phax - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Phax (GFP-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Phax (GFP-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Phax (GFP-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Phax (GFP-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Phax (Myc-DDK-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Phax (Myc-DDK-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, Phax (Myc-DDK-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Phax (Myc-DDK-tagged) - Mouse phosphorylated adaptor for RNA export (Phax), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Phax (GFP-tagged ORF) - Rat phosphorylated adaptor for RNA export (Phax), 200 uL, >10^7 TU/mL

Lenti ORF particles, Phax (GFP-tagged ORF) - Rat phosphorylated adaptor for RNA export (Phax), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Phax (Myc-DDK-tagged ORF) - Rat phosphorylated adaptor for RNA export (Phax), 200 uL, >10^7 TU/mL

Lenti ORF particles, Phax (Myc-DDK-tagged ORF) - Rat phosphorylated adaptor for RNA export (Phax), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

16 Item(s)

per page
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