PHLPP1 antibody

Principal name

PHLPP1 antibody

Alternative names for PHLPP1 antibody

PHLPP, PLEKHE1, SCOP, KIAA0606, PH domain leucine-rich repeat-containing protein phosphatase 1, Pleckstrin homology domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein

SwissProt ID

O60346 (Human), Q09564 (Caeel), Q8CHE4 (Mouse), Q9VJ07 (Drome), Q9WTR8 (Rat)

Gene ID

23239 (PHLPP1), 98432 (Phlpp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PHLPP1 antibody

PHLPP1 Antibody: PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kises (AKT1, AKT2, AKT3) and conventiol/novel protein kise C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and ictivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin sigling.

General readings

Gao T, Furnari F and Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 2005; 18:13–24.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PHLPP1 antibody

Immunohistochemistry-Paraffin: PHLPP Antibody [NB100-1811] - Detection of Human PHLPP by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PHLPP used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. Rabbit Aff - Purified Hu, Ms IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

PHLPP1 (N-term) antibody

Western blot analysis of PHLPP1 in SW480 cell lysate with PHLPP1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PHLPP1 (N-term) antibody

Western blot analysis of anti-PHLPP1 Antibody (N-term) in K562 cell line lysates (35ug/lane).PHLPP1 (arrow) was detected using the purified Pab (1:60dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PHLPP1 (N-term) Control Peptide

PHLPP1
50 µg / €160.00
  Acris Antibodies GmbH

PHLPP1 antibody

Western blot analysis of PHLPP polyclonal antibody ( Cat # PAB3527 ) in K-562 cell line lysates ( 35 µg/lane ) .PHLPP1 ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PHLPP1 antibody

Western blot analysis of PHLPP expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PHLPP1 antibody

Western blot analysis of PHLPP expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PHLPP1 antibody

Western blot analysis of PHLPP expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PHLPP1 antibody

PHLPP1 Rabbit IgG Aff - Purified Hu, Ms WB
50 µg / €680.00
  Funakoshi Co., Ltd.

PHLPP1 antibody

Western Blot and Immunoprecipitation: PHLPP Antibody [NB100-1810] - Detection of Human PHLPP on HeLa whole cell lysate using NB100-1810 and NB100-1811. Immunoprecipitated PHLPP blotted with NB100-1810. Rabbit Aff - Purified Hu IP
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PHLPP1

PHLPP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PHLPP1 overexpression lysate

PHLPP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

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