Phospholamban antibody

Principal name

Phospholamban antibody

Alternative names for Phospholamban antibody

Cardiac phospholamban, PLB, PLN

SwissProt ID

A4IFH6 (Bovin), P26677 (Chick), P26678 (Human), P61012 (Canfa), P61013 (Pig), P61014 (Mouse), P61015 (Rabit), P61016 (Rat)

Gene ID

5350 (PLN), 18821 (Pln), 64672

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of Phospholamban antibody

Phospholamban (PLB/PLN) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains cAMP-dependent protein kinase phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer. PLB is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

General readings

1. Møller DV, Pham TT, Gustafsson F, Hedley P, Ersbøll MK, Bundgaard H, Andersen CB, Torp-Pedersen C, Køber L, Christiansen M. The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2009 Nov 11 (11): 1031-5. PMID: 19875404

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Phospholamban (N-term) antibody

  Goat Anti-Phospholamban / PLN Antibody  
(0.03ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Phospholamban antibody

  Rabbit polyclonal anti-PLN antibody (N-term)  
Western blot analysis of lysate from U266 cell line,using PLN Antibody (N-term)(Cat. #TA328116).TA328116 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane. Rabbit RB44799 Purified Bov, Hu, Ms, Por, Rb, Rt WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Phospholamban (N-term) antibody

Western blot with Phospholamban Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Phospholamban (pThr7) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue using PLB-Thr17 Cat.-No AP53332PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PLB-T17 Antibody for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Phospholamban antibody

Phospholamban Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Phospholamban antibody

Western blot of rat heart tissue lysate with PLN polyclonal antibody ( Cat # PAB13686 ). Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Phospholamban pSer16/pThr17 antibody

Immunofluorescence analysis of HuvEc cells, using PLB (Phospho-Ser16+Thr17) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €205.00
  Assay Biotech

Phospholamban pSer16/pThr17 antibody

Immunofluorescence analysis of HuvEc cells, using PLB (Phospho-Ser16+Thr17) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

Phospholamban antibody

Immunofluorescence analysis of HeLa cells, using PLB (Ab-16/17) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €205.00
  Assay Biotech

Phospholamban antibody

Immunofluorescence analysis of HeLa cells, using PLB (Ab-16/17) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

Phospholamban antibody

Phospholamban Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

CRISPR

Catalog No. Species Donor Vector  

PLN - human gene knockout kit via CRISPR

PLN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PLN - human gene knockout kit via CRISPR

PLN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Phospholamban

Phospholamban Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Phospholamban

Phospholamban Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PLN (mGFP-tagged) - Human phospholamban (PLN), 200 uL, >10^7 TU/mL

Lenti ORF particles, PLN (mGFP-tagged) - Human phospholamban (PLN), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, PLN (Myc-DDK tagged) - Human phospholamban (PLN) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PLN (Myc-DDK tagged) - Human phospholamban (PLN) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Pln (GFP-tagged) - Mouse phospholamban (Pln), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Pln (GFP-tagged) - Mouse phospholamban (Pln), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Pln (GFP-tagged) - Mouse phospholamban (Pln), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Pln (GFP-tagged) - Mouse phospholamban (Pln), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Pln (Myc-DDK-tagged) - Mouse phospholamban (Pln), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Pln (Myc-DDK-tagged) - Mouse phospholamban (Pln), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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