PHOX2B antibody

Principal name

PHOX2B antibody

Alternative names for PHOX2B antibody

PMX2B, Neuroblastoma Phox, NBPhox, Paired mesoderm homeobox protein 2B, PHOX2B homeodomain protein, Paired-like homeobox 2B

SwissProt ID

Q99453 (Human)

Gene ID

8929 (PHOX2B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PHOX2B antibody

PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determints of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one D binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

General readings

Rudzinski, E., et al. Pediatr. Dev. Pathol. 13(4): 291-299 (2010).
Janoueix-Lerosey, I., et al. Oncogene 29(11): 1566-1579 (2010).
Tu, E., et al. Hum. Pathol. 41(3): 392-400 (2010).
Arai, H., et al. J. Hum. Genet. 55(1): 4-7 (2010).
Dubreuil, V., et al. J. Neurosci. 29(47): 14836-14846 (2009).

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PHOX2B (Center) antibody

PHOX2B Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PHOX2B (Center) antibody

PHOX2B Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PHOX2B (Center) Control Peptide

50 µg / €160.00
  Acris Antibodies GmbH


Catalog No.    

PHOX2B overexpression lysate

PHOX2B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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