PIAS2 antibody

Principal name

PIAS2 antibody

Alternative names for PIAS2 antibody

PIASX, ARIP3, DAB2-interacting protein, DIP, Miz1, PIAS-NY protein, E3 SUMO-protein ligase PIAS2, Androgen receptor-interacting protein 3, Msx-interacting zinc finger protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2

SwissProt ID

O75928 (Human), Q6AZ28 (Rat), Q8C5D8 (Mouse)

Gene ID

9063 (PIAS2), 17344 (Pias2)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Eq (Equine), Hst (Hamster), Mky (Monkey), Prim (Primate), Rb (Rabbit), Bear, Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of PIAS2 antibody

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizingThe interaction between UBE2I andThe substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptiol coregulation in various cellular pathways, includingThe STAT pathway,The p53 pathway andThe steroid hormone sigling pathway.The effects ofThis transcriptiol coregulation, transactivation or silencing may vary depending uponThe biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptiol activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160'.

General readings

Sakurai,T., et al., (2004) J. Biol. Chem. 279 (15), 15505-15514

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PIAS2 antibody

  Rabbit Polyclonal Anti-PIAS2 Antibody  
WB Suggested Anti-PIAS2 Antibody Titration: 0.6 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS2 (185-196) antibody

Antibody (AP23730PU-N) (1µg/ml) staining of Human Peripheral Lymphocytes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PIAS2 antibody

  Goat Anti-PIAS2 Antibody  
TA305708 (3.8ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Can, Hu, Ms, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit polyclonal anti-PIAS2 antibody  
Western blot analysis of extracts from COS7 cells, using PIAS2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PIAS2 (N-term) antibody

  Rabbit Polyclonal PIAS2 Antibody  
Western blot analysis of PIAS2 in rat brain tissue lysate with PIAS2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit anti-PIAS2 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PIAS2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit Polyclonal Anti-PIAS2 Antibody  
WB Suggested Anti-PIAS2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit Polyclonal Anti-PIAS2 Antibody  
WB Suggested Anti-PIAS2 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:2500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit Polyclonal Anti-Pias2 Antibody  
WB Suggested Anti-Pias2 Antibody Titration: 0.2-1 ug/ml; Positive Control: NIH/3T3 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit Polyclonal Anti-PIAS2 Antibody  
Western blot analysis on COS7 cell lysate using PIAS2 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  Rabbit Polyclonal Anti-PIAS2 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (PIAS2 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PIAS2 antibody

  PIAS2 mouse monoclonal antibody, clone OTI2B5 (formerly 2B5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PIAS2 (RC212659, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PIAS2.(1:2000) Mouse IgG1 OTI2B5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIAS2 antibody

Western blot (WB) analysis of PIAS2 antibody (Cat.-No.: AP06453PU-N) in extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PIAS2 (PIASx1/2) (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PIAS2 (431-445) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with PIAS2 antibody AP22538PU-N at 3.75 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bt, Can, Elephant, Eq, Hu, Rb E, P
50 µg / €470.00
  Acris Antibodies GmbH

PIAS2 antibody

Western blot analysis of extracts from COS7 cells, using PIAS2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

PIAS2 antibody

Western blot analysis of extracts from COS7 cells, using PIAS2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

PIAS2 - human gene knockout kit via CRISPR

PIAS2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PIAS2 - human gene knockout kit via CRISPR

PIAS2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PIAS2 - human gene knockout kit via CRISPR

PIAS2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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