PIAS4 antibody

Principal name

PIAS4 antibody

Alternative names for PIAS4 antibody

PIASG, PIAS-gamma, PIASy, E3 SUMO-protein ligase PIAS4, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma

SwissProt ID

Q8N2W9 (Human), Q9JM05 (Mouse)

Gene ID

51588 (PIAS4)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP), Dot blot (Dot)

Background of PIAS4 antibody

The interaction of a cytokine with its specific cell surface receptor triggers the activation of intracellular signaling pathways that ultimately program the cellular response. The signal transducers and activators of transcription (STAT) proteins play important roles in the activation of these pathways. Recently, a family of proteins has been identified that inhibits activated STATS and are named as Protein Inhibitors of Activated STAT (PIAS). PIAS proteins comprise a family of five mammalian proteins, which have been identified as potentially important down regulators of the STAT-signaling pathway. The cDNA for mouse and human PIASg encodes a protein of 507 amino acids that is highly homologous to the human protein and is expressed in the mouse as early as d 7.5 of gestation. In situ hybridizations of staged mouse embryos localized the transcript for the PIAS gamma gene to the limbs, neuroepithelium, and the inner root sheath of the hair follicle, suggesting a role in the development of these structures. This protein is also present in hair follicle of human scalp hair and in monkey neuronal cells. Thus PIASg exhibits a highly selective pattern of expression, suggesting that it modulates the response of cells to developmental cues.

General readings

General / background references:Kile BT et al. Negative regulators of cytokine signaling. Int J Hematol 73:292-8 (2001). PubMed PMID: 11345194
Sturm S et al. Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons. J Mol Neurosci 14:107-21 (2000). PubMed PMID: 10854042
Schindler C & Darnell JE Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-51 (1995). PubMed PMID: 7574495
Uddin S et al. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J Biol Chem 270:24627-30 (1995). PubMed PMID: 7559568

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PIAS4 antibody

Western blot analysis of extracts from Jurkat cells, using PIAS4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PIAS4 (N-term) antibody

Western blot analysis of PIAS4 in rat brain tissue lysate with PIAS4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS4 antibody

WB Suggested Anti-PIAS4 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PIAS4 antibody

Western blot analysis of PIAS4 expression in Jurkat cell extract Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIAS4 antibody

Immunohistochemistry (IHC) analyzes of PIAS4 antibody (Cat.-No.: AP06455PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PIAS4 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PIAS4 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PIAS4 control peptide

PIAS4
50 µg / €160.00
  Acris Antibodies GmbH

PIAS4 antibody

PIAS4 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

PIAS4 antibody

Western blot analysis of PIAS4 in A ) human liver, B ) mouse liver, C ) rat liver and D ) human Jurkat lysate using PIAS4 polyclonal antibody ( Cat # PAB0167 ) at 5 µg/ml. Rabbit Hu ICC/IF, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PIAS4 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the PIAS4 polyclonal antibody ( Cat # PAB2257 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, IP, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

PIAS4 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the PIAS4 polyclonal antibody ( Cat # PAB2258 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PIAS4 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using PIAS4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €205.00
  Assay Biotech

PIAS4 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using PIAS4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €310.00
  Assay Biotech

PIAS4 antibody

Human Jurkat; WB Suggested Anti-PIAS4 Antibody Titration: 0.2-1 ug/ml. Positive Control: Jurkat cell lysate; PIAS4 antibody - N-terminal region (ARP33011_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PIAS4 antibody

Western Blot: PAIAS gamma Antibody [NB600-1318] - Western blot analysis of PIASg in Jurkat cell lysate using NB600-1318 at 2 ug/ml. Rabbit IgG Purified Hu WB
0.1 mg / €320.00
  Novus Biologicals Inc.

PIAS4 antibody

Immunohistochemistry: PIASy Antibody [NBP1-31215] - Immunohistochemical analysis of paraffin-embedded DLD1 Xenograft, using PIASy antibody at 1:100 dilution. Rabbit IgG Hu Dot, ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

PIAS4 antibody

PIAS4 Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

PIAS4 antibody

PIAS4 Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €290.00
  Novus Biologicals Inc.

PIAS4 antibody

Immunohistochemistry-Paraffin: PIASy Antibody [NBP1-77161] - Rat brain tissue with PIAS4 antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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