PIK3CA antibody

Principal name

PIK3CA antibody

Alternative names for PIK3CA antibody

PIK3CA, EC=2.7.1.153, PI3-kinase p110 subunit alpha, PtdIns-3-kinase p110, PI3K, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

SwissProt ID

P32871 (Bovin), P42336 (Human), P42337 (Mouse)

Gene ID

5290 (PIK3CA)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Chk (Chicken)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of PIK3CA antibody

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

General readings

Lopez-Knowles E, Hernandez S, Malats N, Kogevinas M, Lloreta J, Carrato A, Tardon A, Serra C, Real FX. PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Res. 2006 Aug 1;66(15):7401-4. PMID: 16885334

  1. Quick-Filters:
  2. Highly Validated (4)

Items 1 to 20 of 25 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PIK3CA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-PIK3CA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801483) Mouse IgG2a OTI6D1 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PIK3CA mouse monoclonal antibody. (TA801592) Dilution: 1:150 Mouse IgG2a OTI6D9 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PIK3CA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA802118) Mouse IgG2a OTI8D6 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CA antibody

Immunofluorescence analysis of HeLa cells using PIK3CA antibody Cat.-No AM06736PU-N (green). Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 4F3 Purified Hu E, F, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

PIK3CA antibody




Human Breast Ductal Carcinoma stained with anti-PI3KCA antibody  


Rabbit IgG SP139 Purified Hu P
0.5 ml / €520.00
  Acris Antibodies GmbH

PIK3CA antibody




Human Breast Ductal Carcinoma stained with anti-PI3KCA antibody  


Rabbit IgG SP139 Purified Hu P
1 ml / €730.00
  Acris Antibodies GmbH

PIK3CA antibody




Human Breast Ductal Carcinoma stained with anti-PI3KCA antibody  


Rabbit IgG SP139 Purified Bov, Chk, Hu, Ms P
0.1 ml / €300.00
  Acris Antibodies GmbH

PIK3CA (Center) antibody

Western blot analysis of anti-PIK3CA Antibody (Center) Pab (Cat.#TA302178) in K562 cell line lysates (35ug/lane). PIK3CA (arrow) was detected using the purified Pab Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIK3CA antibody

TA303167 (2.5µg/ml) staining of paraffin embedded Human Brain (Cerebellar Cortex). Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIK3CA antibody

Western blot analysis of PI3-Kinase with lysate from Jurkat cells. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIK3CA antibody

Western blot analysis of PI3 kinase P110a expression in mouse liver Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PIK3CA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-PIK3CA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801482) Mouse IgG2a OTI7A7 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CA (878-891) antibody

AP08816PU-N staining PIK3CA in paraffin-embedded Human Heart by Immunohistochemistry. Goat IgG Aff - Purified Bear, Bov, Bt, Chk, Elephant, Eq, Fi, Hst, Hu, L, Mky, Ms, Op, Platypus, Prim, Rb, Rt, Tr E, P
50 µg / €470.00
  Acris Antibodies GmbH

PIK3CA antibody

Western blot analysis of anti-PK3CA Antibody in mouse heart tissue lysates (35ug/lane). PK3CA (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PIK3CA antibody

Immunohistochemistry (IHC) analyzes of PI 3-kinase p110alpha antibody (Cat.-No.: AP20582PU-N) in paraffin-embedded human lymph node tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PIK3CA antibody

PIK3CA Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

PIK3CA antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between APPL1 and PIK3CA HeLa cells were stained with anti-APPL1 rabbit purified polyclonal 1:1200 and anti-PIK3CA mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG1 3G3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

PIK3CA antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with PIK3CA polyclonal antibody ( Cat # PAB2126 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PIK3CA antibody

PIK3CA polyclonal antibody ( Cat # PAB7153 ) ( 2.5 µg/ml ) staining of paraffin embedded human brain ( cerebellar cortex ) . Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu E, P
0.1 mg / €400.00
  Abnova Taiwan Corp.

PIK3CA antibody

NB100-55408 (2.5ug/ml) staining of paraffin embedded Human Brain (Cerebellar Cortex). Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P
0.1 mg / €400.00
  Novus Biologicals Inc.

Items 1 to 20 of 25 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn