PIK3CD antibody

Principal name

PIK3CD antibody

Alternative names for PIK3CD antibody

PI3-kinase subunit delta, PI3K-delta, PtdIns-3-kinase subunit delta, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform, PtdIns-3-kinase subunit p110-delta

SwissProt ID

O00329 (Human), O35904 (Mouse)

Gene ID

5293 (PIK3CD)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot), Immunoprecipitation (IP)

Background of PIK3CD antibody

Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration.

General readings

This product has been used in:Vanhaesebroeck B et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A 94:4330-5 (1997). PubMed PMID: 9113989

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PIK3CD antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PIK3CD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801780) Mouse IgG1 OTI6A12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CD antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PIK3CD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801781) Mouse IgG2b OTI1B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CD antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-PIK3CD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801847) Mouse IgG1 OTI1D11 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CD antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PIK3CD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801891) Mouse IgG2a OTI2H3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CD antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PIK3CD mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801924) Mouse IgG1 OTI2D9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CD (C-term) antibody

Western blot analysis of anti-PI3KCD Pab (Cat. #TA325014) in Jurkat cell lysate. PI3KCD (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PIK3CD (N-term) antibody

Western blot analysis of anti-PI3KCD Antibody (N-term) Pab (TA325015) in 293 cell line lysates. PI3KCD Antibody (N-term)(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PIK3CD antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PIK3CD (RC214047, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PIK3CD. Mouse IgG2b OTI1F8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PIK3CD pTyr524 antibody

Dot blot analysis of anti-PIK3CD-pTyr524 Phospho-specific Pab (Cat#AP12879PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

PIK3CD pTyr485 antibody

Dot blot analysis of anti-PIK3CD-pTyr485 Pab (Cat#AP12908PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

PIK3CD antibody

PIK3CD Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

PIK3CD antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with PIK3CD polyclonal antibody ( Cat # PAB3214 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PIK3CD antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with PIK3CD polyclonal antibody ( Cat # PAB3215 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PIK3CD pTyr524 antibody

Dot blot analysis of PIK3CD (phospho Y524) polyclonal antibody ( Cat # PAB8136 ) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/ml. Rabbit Hu Dot, E
0.4 ml / €400.00
  Abnova Taiwan Corp.

PIK3CD antibody

Western blot analysis of PI3K p110 delta expression in K562 (A); Raji (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PIK3CD antibody

Western blot analysis of PI3K p110 delta expression in K562 (A); Raji (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PIK3CD antibody

Western blot analysis of PI3K p110 delta expression in K562 (A); Raji (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PIK3CD antibody

PIK3CD Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

PIK3CD antibody

Immunohistochemistry-Paraffin: PERK Antibody [NBP1-78017] - PERK. Positive staining signal observed in wild type mouse sample with anti-PERK staining only (middle image), but not in the knock out mouse sample (right image) and pre-immune serum staining (left image) The anti-PERK was diluted 1:1,000 in 5% goat serum in PBS and allowed to incubate for 2h at room temperature in a humidified chamber. Rabbit Purified Ms E, ICC/IF, IP, P, WB
0.1 ml / €510.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PIK3CD

PIK3CD Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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