PION / GSAP antibody

Principal name

PION / GSAP antibody

Alternative names for PION / GSAP antibody

Gamma-secretase-activating protein, Protein pigeon homolog

SwissProt ID

A4D1B5 (Human), Q3TCV3 (Mouse)

Gene ID

54103 (PION)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PION / GSAP antibody

PION Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-termil fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-termil fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.

General readings

He, G., et al. Nature 467(7311):95-98(2010)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005).

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PION / GSAP antibody

Western Blot: GSAP Antibody - WB analysis of GSAP in HepG2. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PION / GSAP (C-term) antibody

Western blot analysis of PION in EL4 cell lysate with PION antibody at 0.25 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PION / GSAP control peptide

Western blot analysis of PION in EL4 cell lysate with PION antibody at 0.25 μg/ml in (A) the absence and (B) the presence of blocking peptide.
50 µg / €160.00
  Acris Antibodies GmbH

PION / GSAP (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle reacted withPION / GSAP (C-term) Antibody (C-term) Cat.-No AP53308PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PION / GSAP antibody

PION / GSAP Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

5 Item(s)

per page
  • LinkedIn