PIP5K1A antibody

Principal name

PIP5K1A antibody

Alternative names for PIP5K1A antibody

PIP5K1-alpha, PIP5KIalpha, PtdIns(4)P-5-kinase 1 alpha, Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha, 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha

SwissProt ID

P70182 (Mouse), Q99755 (Human)

Gene ID

8394 (PIP5K1A), 18720 (Pip5k1a)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of PIP5K1A antibody

Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PIP5K1A antibody

  Rabbit Polyclonal Anti-PIP5K1A Antibody  
Host: Rabbit; Target Name: Pip5k1a; Sample Tissue: Mouse Lung lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PIP5K1A antibody

  Rabbit Polyclonal Anti-PIP5K1A Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: PC3 cells, 293T cells, Primary antibody: (PIP5K1A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PIP5K1A (N-term) antibody

Western blot analysis of anti-PIP5K1A Pab in HeLa cell lysate. PIP5K1A (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PIP5K1A antibody

PIP5K1A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PIP5K1A antibody

PIP5K1A Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PIP5K1A antibody

Western blot analysis of PIP5K1A polyclonal antibody ( Cat # PAB3232 ) in HeLa cell lysate. PIP5K1A ( arrow ) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

PIP5K1A - human gene knockout kit via CRISPR

PIP5K1A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PIP5K1A - human gene knockout kit via CRISPR

PIP5K1A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PIP5K1A - human gene knockout kit via CRISPR

PIP5K1A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PIP5K1A - human gene knockout kit via CRISPR

PIP5K1A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pip5k1a - mouse gene knockout kit via CRISPR

Pip5k1a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pip5k1a - mouse gene knockout kit via CRISPR

Pip5k1a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pip5k1a - mouse gene knockout kit via CRISPR

Pip5k1a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pip5k1a - mouse gene knockout kit via CRISPR

Pip5k1a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PIP5K1A

PIP5K1A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PIP5K1A

PIP5K1A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PIP5K1A

PIP5K1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PIP5K1A

PIP5K1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PIP5K1A overexpression lysate

PIP5K1A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

PIP5K1A overexpression lysate

PIP5K1A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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