PITX3 / PTX3 antibody

Principal name

PITX3 / PTX3 antibody

Alternative names for PITX3 / PTX3 antibody

Pituitary homeobox 3, Homeobox protein PITX3, Paired-like homeodomain transcription factor 3

SwissProt ID

O35160 (Mouse), O75364 (Human), P81062 (Rat), Q9I8K3 (Xenla)

Gene ID

5309 (PITX3), 18742 (Pitx3)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PITX3 / PTX3 antibody

The paired-like homeodomain transcription factor-3 (PiTX3) is a member of the homeodomain family of DNA binding proteins known as the RIEG/PITX homeobox gene family .1 The PiTX (PTX) family of homeobox transcription factors includes PiTX1, PiTX2 and PiTX3. PiTX3 is associated with early ocular development and is later expressed in other organs and limbs.1 PiTx3 is expressed in the eyes (specifically the developing lens), and has a highly restricted expression pattern in the brain. PiTx3 expression in the midbrain starts just before terminal differentiation of dopaminergic neurons (DA). PiTX3 can act on the promoter of the Tyrosine hydroxylase (TH) gene in a cell-type dependent fashion, suggesting that PiTX3 contributes to the regulation of TH expression in mesDA.2 A double deletion of the mouse PiTX3 gene causes arrested len development in the recessive aphakia (ak) mouse mutant, which is characterized by small eyes that lack lenses.3 Mutations of the PiTX3 gene have been associated with anterior segment dysgenesis and a familial form of congenital cataracts.1 PiTX3 is required for motor activity and for survival of mesDA. The degeneration of mesDA is the cause of Parkinson's disease (PD)4 and results in striatial dopamine deficiency and hypokinetic movement disorder.

General readings

Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A.
A MicroRNA feedback circuit in midbrain dopamine neurons.
Science. 2007 Aug 31;317(5842):1220-4.
PMID: 17761882

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PITX3 / PTX3 antibody

TA303322 (1µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PITX3 / PTX3 antibody

WB Suggested Anti-PITX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

PITX3 / PTX3 antibody

WB Suggested Anti-PITX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PITX3 / PTX3 antibody

WB Suggested Anti-PITX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

PITX3 / PTX3 (N-term) antibody

Brain, cortex, white matter: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Ms ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

PITX3 / PTX3 antibody

PITX3 polyclonal antibody ( Cat # PAB7438 ) ( 1 µg/ml ) staining of human cerebellum lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PITX3 / PTX3 antibody

Hum. Fetal Liver; Host: Rabbit . Target Name: PITX3 . Sample Tissue: Human Fetal Liver . Antibody Dilution: 1.0ug/ml.; PITX3 antibody - middle region (ARP33032_P050) in Hum. Fetal Liver cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PITX3 / PTX3 antibody

Human 293T; Host:Rabbit. Target Name:PITX3. Sample Tissue:293T. Antibody Dilution: 1.0ug/ml. PITX3 is supported by BioGPS gene expression data to be expressed in HEK293T.; PITX3 antibody - N-terminal region (ARP33033_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PITX3 / PTX3 antibody

Human HepG2; WB Suggested Anti-PITX3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: HepG2 cell lysate; PITX3 antibody - N-terminal region (ARP38544_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PITX3 / PTX3 antibody

Western Blot: PITX3 Antibody [NB100-96910] - (1µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PITX3 / PTX3 antibody

Immunohistochemistry-Paraffin: PITX3 Antibody [NBP1-92274] Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity, with a granular pattern in Purkinje cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

PITX3 overexpression lysate

PITX3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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