PJA1 / RNF70 antibody

Principal name

PJA1 / RNF70 antibody

Alternative names for PJA1 / RNF70 antibody

Praja1, Praja-1, RING finger protein 70, E3 ubiquitin-protein ligase Praja-1

SwissProt ID

O55176 (Mouse), Q8NG27 (Human)

Gene ID

64219 (PJA1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PJA1 / RNF70 antibody

Ubiquitinization is an important cellular degradation process requiring sequential reactions that are mediated by three enzymes: E1, E2 and E3. PJA1, also known as Praja1 and RING finger protein 70, is a 643 amino acid E2-dependent E3-ubiquitin ligase that is abundantly expressed in the brain (1,2). Through interaction and activation with the E2-ubiquitin ligase UBC4, PJA1 mediates substrate-specific ubiquitition via its RING finger domain and facilitates ubiquitition (3). Overexpression of PJA1 in gastrointestil cancers suggests that it may be responsible for the degradation of some anti-oncogenic proteins (4,5).

General readings

Wieland, I., et al. Clin. Genet. 72(6):506-516(2007)
Saha, T., et al. Oncogene 25(5):693-705(2006)
Mishra, L., et al. Cancer Biol. Ther. 4(7):694-699(2005)
Sasaki, A., et al. J. Biol. Chem. 277(25):22541-22546(2002)
Yu, P., et al. Genomics 79(6):869-874(2002)

7 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PJA1 / RNF70 antibody

Western blot analysis of PJA1 in human brain tissue lysate with PJA1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PJA1 / RNF70 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue reacted with  PJA1 / RNF70 Antibody (N-term) Cat.-No AP53313PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of PJA1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PJA1 / RNF70 antibody

PJA1 / RNF70 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PJA1 / RNF70 antibody

PJA1 / RNF70 Mouse IgG2a 3E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PJA1 / RNF70 antibody

Immunohistochemistry-Paraffin: RNF70 Antibody [NBP1-87399] - Immunohistochemistry-Paraffin: RNF70 Antibody [NBP1-87399] Immunohistochemical staining of human esophagus shows nuclear positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PJA1 / RNF70

PJA1 / RNF70 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PJA1 / RNF70

PJA1 / RNF70 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

7 Item(s)

per page
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