PLA2G1B antibody

Principal name

PLA2G1B antibody

Alternative names for PLA2G1B antibody

PLA2G1B, PLA2, PLA2A, PPLA2, Phospholipase A2, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B

SwissProt ID

P00592 (Pig), P00593 (Bovin), P00594 (Horse), P04054 (Human), P04055 (Rat), P06596 (Canfa), P14419 (Sheep), Q7M334 (Rabit), Q9Z0Y2 (Mouse)

Gene ID

5319 (PLA2G1B), 445525, 18778 (Pla2g1b), 29526

Available reactivities

Hu (Human), Por (Porcine), Can (Canine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R)

Background of PLA2G1B antibody

Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators. The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of low-molecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense. This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso-PC and free fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci. In mice, sPLA2 expression significantly influences HDL particle size and composition and demonstrate that an induction of sPLA2 is required for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aggregates in rats.

General readings

Kolko M, Christoffersen NR, Varoqui H, Bazan NG.
Expression and induction of secretory phospholipase A2 group IB in brain.
Mol Neurobiol. 2005 Nov;25(7):1107-22.
PMID: 16392040.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLA2G1B (C-term) antibody

  Goat Polyclonal Antibody against PLA2G1B  
TA302575 (0.01µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PLA2G1B antibody

PLA2G1B Rabbit IgG Azide Free Por Dot, E, ICC/IF, ID, IP, R, WB
10 mg / €240.00
  Acris Antibodies GmbH

PLA2G1B antibody

PLA2G1B Rabbit IgG Biotin Por Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €350.00
  Acris Antibodies GmbH

PLA2G1B antibody

PLA2G1B Rabbit IgG Aff - Purified Por Dot, E, ICC/IF, ID, IP, R, WB
1 mg / €440.00
  Acris Antibodies GmbH

PLA2G1B antibody

PLA2G1B Rabbit Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PLA2G1B - human gene knockout kit via CRISPR

PLA2G1B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PLA2G1B - human gene knockout kit via CRISPR

PLA2G1B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PLA2G1B - human gene knockout kit via CRISPR

PLA2G1B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PLA2G1B - human gene knockout kit via CRISPR

PLA2G1B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pla2g1b - mouse gene knockout kit via CRISPR

Pla2g1b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Pla2g1b - mouse gene knockout kit via CRISPR

Pla2g1b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pla2g1b - mouse gene knockout kit via CRISPR

Pla2g1b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Pla2g1b - mouse gene knockout kit via CRISPR

Pla2g1b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PLA2G1B

  Recombinant protein of human phospholipase A2, group IB (pancreas) (PLA2G1B)  
PLA2G1B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PLA2G1B (His-tagged Fusion Protein)

12% SDS-PAGE separation of Human sPLA2-IB. 1: M.W. marker - 14, 21, 31, 45, 66, 97 kDa. 2: reduced and heated sample, 5µg/lane. 3: non-reduced and non-heated sample, 5µg/lane. Human Purified > 95 % > 95% E. coli
0.1 mg / €470.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

PLA2G1B overexpression lysate

PLA2G1B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PLA2G1B (mGFP-tagged) - Human phospholipase A2, group IB (pancreas) (PLA2G1B), 200 uL, >10^7 TU/mL

Lenti ORF particles, PLA2G1B (mGFP-tagged) - Human phospholipase A2, group IB (pancreas) (PLA2G1B), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, PLA2G1B (Myc-DDK tagged) - Human phospholipase A2, group IB (pancreas) (PLA2G1B) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PLA2G1B (Myc-DDK tagged) - Human phospholipase A2, group IB (pancreas) (PLA2G1B) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Pla2g1b (GFP-tagged) - Mouse phospholipase A2, group IB, pancreas (Pla2g1b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pla2g1b (GFP-tagged) - Mouse phospholipase A2, group IB, pancreas (Pla2g1b), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Pla2g1b (Myc-DDK-tagged) - Mouse phospholipase A2, group IB, pancreas (Pla2g1b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pla2g1b (Myc-DDK-tagged) - Mouse phospholipase A2, group IB, pancreas (Pla2g1b), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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