PLA2G4A antibody

Principal name

PLA2G4A antibody

Alternative names for PLA2G4A antibody

cPLA2, phospholipase A2, Cytosolic phospholipase A2, Phospholipase A2 group IVA

SwissProt ID

A4IFJ5 (Bovin), P47712 (Human), P47713 (Mouse), P49147 (Chick), P50393 (Rat), Q7T0T9 (Xenla), Q9TT38 (Rabit)

Gene ID

5321 (PLA2G4A), 18783 (Pla2g4a), 945321 (abrB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of PLA2G4A antibody

HTATIP (HIV-1 Tat interacting protein TIP60, about 60kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

General readings

1. Singh NK  et al. Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKC?-cPLA(2) activation and retinal neovascularization. Blood 121:1911-23 (2013). Human .PubMed: 23319572
2. Estevez B  et al. LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood 121:4586-94 (2013). Mouse .PubMed: 23620575
3. Ma L  et al. An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model. Mol Pain 9:29 (2013). IHC-Fr ; Mouse .PubMed: 23773289
4. Zhang Q  et al. Activation of Cytosolic Phospholipase A2 Downstream of the Src-Phospholipase D1 (PLD1)-Protein Kinase C {gamma} (PKC{gamma}) Signaling Axis Is Required for Hypoxia-induced Pathological Retinal Angiogenesis. J Biol Chem 286:22489-98 (2011). WB ; Human .PubMed: 21536681
5. Kishimoto K  et al. Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice. J Neuroinflammation 7:42 (2010). WB ; Mouse .PubMed: 20673332
6. Manosalva I & González A Aging alters histone H4 acetylation and CDC2A in mouse germinal vesicle stage oocytes. Biol Reprod 81:1164-71 (2009).PubMed: 19641176

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLA2G4A antibody

(1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PLA2G4A antibody

Western blot analysis of c-PLA2 expression in TNF-a treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLA2G4A antibody

Western blot analysis of PLA2G4A Antibody (Center) (AP17650PU-N) in NCI-H460 cell line lysates (35ug/lane). PLA2G4A (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PLA2G4A antibody

PLA2G4A Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

PLA2G4A antibody

Detection limit for recombinant GST tagged PLA2G4A is approximately 0.3ng/ml as a capture antibody. Mouse IgG1 10G5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PLA2G4A antibody

PLA2G4A Rabbit Ms WB
1 mg / €640.00
  Abnova Taiwan Corp.

PLA2G4A pSer505 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using c-PLA2 (Phospho-Ser505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

PLA2G4A pSer505 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using c-PLA2 (Phospho-Ser505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

PLA2G4A antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using c-PLA2 (Ab-505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

PLA2G4A antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using c-PLA2 (Ab-505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

PLA2G4A antibody

PLA2G4A Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

PLA2G4A pSer505 antibody

Immunohistochemical analysis of PLA2G4A (pS505) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

PLA2G4A pSer505 antibody

Immunohistochemical analysis of PLA2G4A (pS505) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

PLA2G4A pSer505 antibody

Immunohistochemical analysis of PLA2G4A (pS505) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Immunohistochemical analysis of PLA2G4A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Immunohistochemical analysis of PLA2G4A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Immunohistochemical analysis of PLA2G4A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Western blot analysis of PLA2G4A expression in A549 (A); HeLa (B); mouse kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Western blot analysis of PLA2G4A expression in A549 (A); HeLa (B); mouse kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Western blot analysis of PLA2G4A expression in A549 (A); HeLa (B); mouse kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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