PLA2G4A antibody

Principal name

PLA2G4A antibody

Alternative names for PLA2G4A antibody

cPLA2, phospholipase A2, Cytosolic phospholipase A2, Phospholipase A2 group IVA

SwissProt ID

A4IFJ5 (Bovin), P47712 (Human), P47713 (Mouse), P49147 (Chick), P50393 (Rat), Q7T0T9 (Xenla), Q9TT38 (Rabit)

Gene ID

5321 (PLA2G4A), 18783 (Pla2g4a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of PLA2G4A antibody

PLA2G4A (Phospholipase A2, Group IVA), is an enzyme that in humans is encoded by the PLA2G4A gene. Tay et al. (1995) mapped the PLA2G4A gene to rat chromosome 13 by PCR-based intercross genotyping and to human 1q25 by fluorescence in situ hybridization. By site-directed mutagenesis and biochemical analysis of the recombinant protein, Sharp et al. (1994) determined that ser228 participates in the catalytic mechanism of cPLA2 and that both the phospholipase A2 and the lysophospholipase activities are catalyzed by the same active site residue(s). PLA2G4A, the cytosolic phospholipase A2, appears to subserve transmembrane signaling responses to extracellular ligands (Skorecki, 1995).

General readings

1. Singh NK  et al. Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKC?-cPLA(2) activation and retinal neovascularization. Blood 121:1911-23 (2013). Human .PubMed: 23319572
2. Estevez B  et al. LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood 121:4586-94 (2013). Mouse .PubMed: 23620575
3. Ma L  et al. An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model. Mol Pain 9:29 (2013). IHC-Fr ; Mouse .PubMed: 23773289
4. Zhang Q  et al. Activation of Cytosolic Phospholipase A2 Downstream of the Src-Phospholipase D1 (PLD1)-Protein Kinase C {gamma} (PKC{gamma}) Signaling Axis Is Required for Hypoxia-induced Pathological Retinal Angiogenesis. J Biol Chem 286:22489-98 (2011). WB ; Human .PubMed: 21536681
5. Kishimoto K  et al. Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice. J Neuroinflammation 7:42 (2010). WB ; Mouse .PubMed: 20673332
6. Manosalva I & González A Aging alters histone H4 acetylation and CDC2A in mouse germinal vesicle stage oocytes. Biol Reprod 81:1164-71 (2009).PubMed: 19641176

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLA2G4A antibody

(1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PLA2G4A antibody

Western blot analysis of c-PLA2 expression in TNF-a treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLA2G4A antibody

Western blot analysis of c-PLA2 phosphorylation expression in TNF-a treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLA2G4A antibody

Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: 293T cells, Primary antibody: (PLA2G4A Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLA2G4A antibody

Western blot analysis of PLA2G4A Antibody (Center) (AP17650PU-N) in NCI-H460 cell line lysates (35ug/lane). PLA2G4A (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PLA2G4A antibody

PLA2G4A Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

PLA2G4A antibody

Detection limit for recombinant GST tagged PLA2G4A is approximately 0.3ng/ml as a capture antibody. Mouse IgG1 10G5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PLA2G4A antibody

PLA2G4A Rabbit Ms WB
1 mg / €640.00
  Abnova Taiwan Corp.

PLA2G4A pSer505 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using c-PLA2 (Phospho-Ser505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

PLA2G4A pSer505 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using c-PLA2 (Phospho-Ser505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

PLA2G4A antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using c-PLA2 (Ab-505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

PLA2G4A antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using c-PLA2 (Ab-505) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

PLA2G4A antibody

PLA2G4A Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

PLA2G4A pSer505 antibody

Immunohistochemical analysis of PLA2G4A (pS505) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

PLA2G4A pSer505 antibody

Immunohistochemical analysis of PLA2G4A (pS505) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

PLA2G4A pSer505 antibody

Immunohistochemical analysis of PLA2G4A (pS505) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Immunohistochemical analysis of PLA2G4A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Immunohistochemical analysis of PLA2G4A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Immunohistochemical analysis of PLA2G4A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PLA2G4A antibody

Western blot analysis of PLA2G4A expression in A549 (A); HeLa (B); mouse kidney (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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